Pairwise key establishment is a fundamental security service in sensor networks; it enables sensor nodes to communicate securely with each other using cryptographic techniques. However, due to the resource constraints on sensor nodes, it is not feasible to use traditional key management techniques such as public key cryptography and key distribution center (KDC). A number of key predistribution techniques have been proposed for pairwise key establishment in sensor networks recently. To facilitate the study of novel pairwise key predistribution techniques, this paper develops a general framework for establishing pairwise keys between sensor nodes using bivariate polynomials. This paper then proposes two efficient instantiations of the general framework: a random subset assignment key predistribution scheme, and a hypercube-based key predistribution scheme. The analysis shows that both schemes have a number of nice properties, including high probability, or guarantee to establish pairwise keys, tolerance of node captures, and low storage, communication, and computation overhead. To further reduce the computation at sensor nodes, this paper presents an optimization technique for polynomial evaluation, which is used to compute pairwise keys. This paper also reports the implementation and the performance of the proposed schemes on MICA2 motes running TinyOS, an operating system for networked sensors. The results indicate that the proposed techniques can be applied efficiently in resource-constrained sensor networks.

Nanotechnology has become more and more potentially used in diagnosis or treatment of diseases. Advances in nanotechnology have led to new and improved nanomaterials in biomedical applications. Common nanomaterials applicable in biomedical applications include liposomes, polymeric micelles, graphene, carbon nanotubes, quantum dots, ferroferric oxide nanoparticles, gold nanoparticles (Au NPs), and so on. Among them, Au NPs have been considered as the most interesting nanomaterial because of its unique optical, electronic, sensing and biochemical properties. Au NPs have been potentially applied for medical imaging, drug delivery, and tumor therapy in the early detection, diagnosis, and treatment of diseases. This review focuses on some recent advances in the use of Au NPs as drug carriers for the intracellular delivery of therapeutics and as molecular nanoprobes for the detection and monitoring of target molecules.

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