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The chromatin remodeling gene, AT-rich interactive domain 1A gene (ARID1A), frequently mutates inactively in gastric cancer (GC). However, its prognostic value remains controversial. To address this issue, a comprehensive meta-analysis was performed. Studies published until March 2016 were systematically searched. A total of 15 cohorts from 14 literatures involving 3183 patients were subjected to this meta-analysis. The pooled data showed that ARID1A expression loss predicted poor overall survival (OS) in GC (Hazard Ratio (HR) = 1.60; 95% Confidence Interval (CI) = 1.40–1.81; P < 0.001), with low heterogeneity among these studies (I2 = 21.5%; P = 0.214). Stratification analyses revealed that ARID1A expression loss was associated with poor OS in Asians (HR = 1.65, 95% CI = 1.44–1.89), proportion of proximal disease ≤30% subgroup (HR = 1.80, 95% CI = 1.36–2.38) and Epstein-Barr virus (EBV) (+) > 5% subgroup (HR = 1.59, 95% CI = 1.18–2.15). The robust results were suggested by sensitivity analyses and no evidence of significant publication bias was detected. This study demonstrated a significant relationship between deletion of ARID1A expression and poor OS in GC. Moreover, ethnicity, tumor location and EBV infection status might be potential key factors influencing this correlation.

Coxsackievirus 6 (CV‐A6) has been emerging as another predominant serotype for severe hand, foot, and mouth disease (HFMD) in China, after the introduction of enterovirus 71 inactivated vaccine (EV71 vaccine) for 3 years. Data on the risk factors for severe HFMD infected with CV‐A6 are limited. We interviewed the caregivers to collected data on HFMD patients who sought medical care in the People's Hospital of Baoan district, Shenzhen, from 2015 to 2017. Totally, 131 severe patients were frequency‐matched by age and gender with 174 mild patients infected with CV‐A6. Univariable and multivariable logistic regression analyses were conducted to analyze the risk factors for severe CV‐A6 HFMD. The average age was 20.62 ± 14.18 months and 20.52 ± 12.76 months for severe and mild patients, respectively. Multivariate analyses indicated complications at birth (odds ratio [OR], 4.18; 95% confidence interval [CI]: 1.64‐10.63), peak body temperature over 39°C (OR, 4.04; 95% CI: 2.29‐7.10) and first‐born child (OR, 2.17; 95% CI: 1.27‐3.70) increased the risk of severe HFMD infected with CV‐A6. Breastfeeding (OR, 0.52; 95% CI: 0.32‐0.87), and washing hands after playing frequently (OR, 0.58; 95% CI: 0.34‐0.97) were negatively associated with severe illness. Compared with HFMD with infection of EV‐A71, complications at birth and first‐born child were newly found to be associated with severe illness in HFMD patients infected with CV‐A6.

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