No abstract

No abstract

Laryngoscopy and intubation contravene the patient's protective airway reflexes and lead to physiological changes involving various systems of the body Reflex changes in the cardiovascular system are more marked after laryngoscopy and intubation Esmolol is an ultra-short acting beta-l adrenergic blocking drug, with cardio selectivity, rapid onset of action and extremely short elimination half-life. AIM OF STUDY: To study the efficacy and safety of attenuation of pressor response during laryngoscopy and tracheal intubation using esmolol, administered in dose of 0.75mg/kg single IV bolus prior to induction of anesthesia. MATERIALS AND METHODS: The study was conducted in 50 patients, who were randomly assigned into 2 groups of 25 each. Group A (25) not received any drug and Group B (25) received Inj. Esmolol 0.75mg/kg I.V before induction. RESULTS: There was an increase in heart rate and blood pressure in the Group A whereas there was a decrease in blood pressure heart rate in the Group B immediately after intubation and at the end of 4 th min. CONCLUSION: In this study, the esmolol group showed a decrease in mean values of Heart Rate, Blood Pressure immediately after administration.

BACKGROUNDLaryngoscopy and endotracheal intubation results in physiological changes of various body systems like heart rate and blood pressure in cardiovascular system. For attenuating the hyperdynamic cardiovascular response to tracheal intubation, numerous trials with many drugs were undertaken.