This is a case report about Porphyria cutanea tarda (PCT) and its relationship with the infection caused by the human immunodeficiency virus (HIV). Cutaneous porphyria is an illness caused by enzymatic modification that results in partial deficiency of uroporphyrinogen decarboxylase (Urod), which may be hereditary or acquired. Several studies suggest that HIV infection associated with cofactors might trigger the development of porphyria cutanea tarda. In this case report, we present a patient infected with HIV, who after the introduction of antiretroviral therapy (ART) enjoyed clinical improvement of porphyria cutanea tarda symptoms.

Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. ABSTRACT Background and Objectives:To estimate the prevalence of Mycobacterium tuberculosis infection in undergraduate medical students and associated factors. An adequate assessment increases the institutional biosafety strategies, in addition to providing adequate chemoprophylaxis. Methods: Cross-sectional study carried out from August 2013 to July 2014, which included 62 undergraduate medical students submitted to tuberculin skin test and interview. The tuberculin test was performed using the Mantoux technique. The test reading was performed by the palpation method, 48 to 72 hours after the injection. The data collected at the interview were: year of medical school, history of atopy, history of hypersensitivity to PPD, BCG vaccination history, vaccination with live attenuated virus in the last 4 weeks, prior tuberculosis, potential exposure, time of exposure. Results:30.6% of students showed reaction at the Mantoux test. The highest prevalence of reagent cases was observed among male students. Conclusion: The prevalence of a strong reaction at the tuberculin test is relatively low among medical students, but relevant for the risk stratification of this population. Justificativa e Objetivos: Estimar a prevalência da infecção pelo Mycobacterium tuberculosis em acadêmicosde medicina e fatores associados. Uma avaliação adequada incrementa as estratégias de biossegurança institucional, além de prover uma quimioprofilaxia adequada. Métodos: Estudo transversal, realizado de agosto de 2013 a julho de 2014 onde foram incluídos 62 estudantes de medicina Foi realizado teste tuberculínico e entrevista. O teste tuberculínico foi realizado através da técnica de Mantoux. A leitura do teste foi realizada pelo método palpatório, 48 a 72 horas após a injeção. Os dados coletados na entrevista foram os seguintes: período que se encontra no curso, história de atopia, história de hipersensibilidade ao PPD, histórico vacinal da BCG, vacinação de vírus vivo atenuado nas últimas 4 semanas, tuberculose prévia, exposição potencial, tempo de exposição. Resultados: 30,6% dos estudantes eram reagentes. A maior prevalência de casos reagentes foi em estudantes do sexo masculino. Conclusão: A prevalência de teste tuberculínico reator forte é relativamente baixa entre os estudantes de medicina, porém relevante para a estratificação de risco desta população.

Introduction: Stevens-Johnson syndrome (SJS) is caused by a delayed immune response triggered by the association of genetic and environmental factors. This reaction can be mediated mainly by some drugs. Objective: The purpose of this article is to report the case of a patient with SJS associated with carbamazepine. Case report: A man was hospitalized complaining of odynophagia, whitish plaques in the mouth and swelling of the lips. Clinical examination revealed ulcerated and erosive lesions involving the buccal mucosa, lips, tongue and hard palate. The lips were swollen and with hemorrhagic crusts. Papular and purplish-colored lesions were observed on the skin. The patient reported that the lesions started 10 days ago, coinciding with the start of carbamazepine use. The diagnosis of SJS was established based on clinical information and the patient treated with support therapy. Conclusion: SJS is a clinical condition that affects the oral mucosa and can be triggered by the use of carbamazepine.

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