Fat necrosis of the breast is a benign condition that most commonly occurs as the result of minor breast trauma. The radiographic and clinical significance of fat necrosis of the breast is that it may mimic a breast malignancy, requiring biopsy for diagnosis. The mammographic appearance of fat necrosis ranges from a lipid cyst to findings suspicious for malignancy, including clustered microcalcifications, a spiculated area of increased opacity, or a focal mass. The changes of fat necrosis may be seen following blunt trauma, cyst aspiration, biopsy, lumpectomy, radiation therapy, reduction mammoplasty, breast reconstruction with a transverse rectus abdominis myocutaneous (TRAM) flap, implant removal, and anticoagulant therapy, as well as in patients without a relevant history. Fat necrosis may also be detected mammographically as an incidental finding in benign lipomas. It is important to recognize the mammographic spectrum of appearances of fat necrosis to avoid unnecessary biopsy and to avoid overlooking breast cancer.

40% (n=38). This study shows that there is unregistered visual impairment in patients attending ophthalmic departments. As registration triggers multidisciplinary support, ophthalmologists need to be more alert to the benefits and criteria for partial sight and blind registration. (BrJ Ophthalmol 1994; 78: 736-740)

The ocular complications in population of 131 premature infants, with and without retinopathy of prematurity (ROP) are reported. An increased incidence of strabismus (20% with ROP and 25% without ROP) and myopia (27-5% with ROP and 8-8% without ROP) was shown. Significant visual loss occurred in 10-7% overall, increasing to 35% with stage 3 disease and 100% with stage 4. With the increased survival rate of premature infants, the relevance to future management of this expanding group of young people is considered. (BrJ7 Ophthalmol 1993; 77: 91-94)

Fixed combination therapies are equally safe and effective at lowering IOP as their non-fixed components administered concomitantly.

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