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Cervical cancer is one of the most common cancers in Indonesia. It can be treated with molecular therapies targeting Matrix metallopeptidase 9 (MMP-9) and Glucose transporter (GLUT-1), which are enzymes that are involved in tumour cell invasion, metastasis and angiogenesis. Zanthoxylum acanthopodium (andaliman) is an Indonesian herb with anti-cancer properties. This study aimed to investigate the histological changes andaliman treatment caused in MMP-9 and GLUT-1 expression. This study used five groups of rats: control (C-), cancer model (C+), cancer-bearing rats with a 100-mg dose of Zanthoxylum acanthopodium methanol extract (ZAM)/BW (ZAM100), cancer-bearing rats with a 200-mg dose of ZAM /BW (ZAM200) and cancer-bearing rats with a 400-mg dose of ZAM/BW (ZAM400). Immunohistochemical methods were used to stain cervical tissue with MMP-9 and GLUT-1 antibodies, and a TUNEL assay was performed to investigate cell apoptosis. Zanthoxylum acanthopodium methanol extract administration did not affect rat body weight but had a significant effect on cervical cancer growth. There was an increase in MDA levels associated with SOD deficiency in tumour tissue. SOD activity increased due to ZAM administration, allowing cells to be protected from oxidant disruption and oxidative stress. ZAM ameliorated cervical carcinoma tissue damage and reduced the expression of MMP-9, GLUT-1 and apoptosis in serum and tissue (p < 0.01) In short, the higher the ZAM dose, the lower the expression of MMP-9, GLUT-1 and apoptosis, indicating that ZAM is effective to treat cervical cancer.

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Background: Cervical cancer is the second cancer disease that attacks women in the world, and it ranked the first in developing countries. It is expected that woman’s knowledge about cervical cancer will prevent the incidence among them.  Objective: To examine the effect of health education on the knowledge level of women about cervical cancer prevention.Methods: This was a pre-experimental study with one group pretest posttest at Bahorok’s Village, North Sumatra, Indonesia on April to May 2016. There were 36 samples selected using purposive sampling. Paired t-test was used for data analysis.Results: There was a significant difference in the mean value of women knowledge levels (p=0.004), with the increase of the mean of knowledge before intervention (mean= 1.0) and knowledge after the intervention (mean= 2.14).Conclusion: There was a significant effect of health education in increasing the level of women knowledge about prevention of cervical cancer. It is suggested that that health education should be done routinely to increase women knowledge in order to prevent cervical cancer.

Background: Schizophrenia is a severe mental illness with the majority of patients’ experiences relapses. Family support is not a new topic, but still considered as an important factor to prevent the relapse. However, little is known about the correlation between family support and relapse in schizophrenia patients in North Sumatra, Indonesia.Objective: This study aims to examine the relationship between family support and relapse in schizophrenia.Methods:  This was a correlational cross sectional study conducted from January to May 2015 at the psychiatric hospital in Medan North Sumatra Indonesia. There were 90 samples selected using purposive sampling. Chi Square test was used to analyze the data.Results: Findings of this study reveals that there was statistically significant relationship between family informational support (p=0.00), appraisal support (p=0.00), instrumental support (p=0.00), and emotional support (p=0.00) with relapse in schizophrenia.Conclusion: There is a significant correlation between family support (informational support, appraisal, instrumental and emotional support) and relapse in schizophrenia. Therefore, it is recommended that health care professional should continuously promote the important of family support and increase their knowledge regarding the type of supports needed for patients with schizophrenia.