No abstract

Background:Recently, the deleterious effects of left bundle branch block (LBBB) on left ventricular systolic function have been taken into consideration.Objectives:The present study aimed to identify underlying factors that predict left ventricular ejection fraction (LVEF) deterioration in patients suffered from complete LBBB.Patients and Methods:In a retrospective case-control study, the data of 220 consecutive patients diagnosed with LBBB on their electrocardiograms were assessed. They were referred to Isfahan Heart Center in Isfahan Province, Iran in 2013. LVEF deterioration was defined as a decrease in LVEF at least 10% between the baseline and follow-up echocardiography study. Thus, achieving the LVEF values ≤ 40% in patients with an initial EF of > 50% was considered LVEF deterioration.Results:Among 220 patients, 40% of LBBB patients suffered LVEF deterioration within 3 months of initial assessment. The group with LVEF deterioration had higher male to female ratio, had higher NYHA score, and suffered more from systolic hypertension than another group. Those with coronary artery disease (CAD) had also significantly lower LVEF than non-CAD ones. Adverse associations were revealed between systolic blood pressure and LVEF measurement (r = -0.193, P = 0.006) as well as between NYHA score and LVEF (r = -0.215, P = 0.002). A multivariable logistic regression model showed that among baseline variables, male gender (OR = 3.218, P < 0.001), history of systolic hypertension (OR = 2.012, P = 0.029), higher NYHA score (OR = 1.623, P = 0.005), and the presence of coronary artery disease (OR = 2.475, P = 0.028) could effectively predict LVEF deterioration in patients with LBBB.Conclusions:Male gender, history of hypertension, high NYHA score, and the presence of CAD predict LVEF deterioration in patients with LBBB.

Background: Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. The aim of the present study is to compare the lipid profile in liver transplant recipients from living-related and deceased donors.Methods: This is a retrospective cross-sectional study performed in Shiraz University of Medical Science between 2005 till 2018. Patients under 18 years old who received liver transplant were included in the study and divided in 2 groups who received from living-related and deceased donors and lipid profiles were compared between two groups.Results: 397 patients were included in the study, in the first group 234 received liver from deceased donor and in second group 161 from living-related donor. The mean TG and HDL level were 133 mg/dL and 46 mg/dL in the first group and 118 mg/dL and 54 mg/dL in the second group while the differences were statistically significant.Conclusion: Patients who received liver from a living-related donor have a significantly lower TG and higher HDL and a lower cardiovascular risk.

Background: Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. The aim of the present study is to compare the lipid profile in liver transplant recipients from living-related and deceased donors.Methods: This is a retrospective cross-sectional study performed in Shiraz University of Medical Science between 2005 till 2018. Patients under 18 years old who received liver transplant were included in the study and divided in 2 groups who received from living-related and deceased donors and lipid profiles were compared between two groups.Results: 397 patients were included in the study, in the first group 234 received liver from deceased donor and in second group 161 from living-related donor. The mean TG and HDL level were 133 mg/dL and 46 mg/dL in the first group and 118 mg/dL and 54 mg/dL in the second group while the differences were statistically significant.Conclusion: Patients who received liver from a living-related donor have a significantly lower TG and higher HDL and a lower cardiovascular risk.