Adipose-derived stem cells (ASCs) are a mesenchymal stem cell source with properties of self-renewal and multipotential differentiation. Compared to bone marrow-derived stem cells (BMSCs), ASCs can be derived from more sources and are harvested more easily. Three-dimensional (3D) tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment, which benefits the localization, attachment, proliferation, and differentiation of ASCs. Therefore, tissue-engineered ASCs are recognized as an attractive substitute for tissue and organ transplantation. In this paper, we review the characteristics of ASCs, as well as the biomaterials and tissue engineering methods used to proliferate and differentiate ASCs in a 3D environment. Clinical applications of tissue-engineered ASCs are also discussed to reveal the potential and feasibility of using tissue-engineered ASCs in regenerative medicine.

Introduction: Depression and anxiety are common among people with rosacea. However, the exact magnitude of the prevalence rate and odds ratios (ORs) for depression and anxiety, respectively, in rosacea patients is unclear, and no systematic review or meta-analysis of published data has yet been performed. We therefore performed as systematic review and metaanalysis to determine the prevalence rates and ORs for depression and anxiety in rosacea patients.Methods: We performed a systematic search of the PubMed, Embase and Medline databases for all observational studies published up to October 2020 that reported the prevalence rates and ORs for depression and anxiety in patients with rosacea. The primary outcome measures were prevalence rates and ORs for depression and anxiety in patients with rosacea. Heterogeneity across studies was assessed with the I 2 statistic. Sources of heterogeneity were explored through subgroup and meta-regression analyses. Results: A total of 14 studies involving 14,134,021 patients with rosacea were included in the systematic review and meta-analysis. The pooled prevalence of depression was 19.6% (95% confidence interval [CI] 15.0-24.3%) and that of anxiety was 15.6% (95% CI 11.8-19.3%). The prevalence of depression and anxiety was significantly lower in studies using clinical criteria to diagnose depression and anxiety (9.2 and 10.2%, respectively) than in those studies using screening tools (26.2% [P \ 0.01] and 22.7% [P = 0.03], respectively). The methodological quality of the included studies greatly contributed to the heterogeneity. Patients with rosacea were more likely to experience depression (OR 2.21, 95% CI 1.79-2.72) and anxiety (OR 2.31, 95% CI 1.56-3.44) than healthy controls. Conclusions: This systematic review and metaanalysis indicates that patients with rosacea are at a higher risk of experiencing depression and anxiety. More efforts are warranted to recognize R. Dai and BJ. Lin contributed equally to this study.

Background Sensitive skin is a common cutaneous condition that affects many people. The exact prevalence of sensitive skin remains unknown. Objectives We aim to perform a systematic review and meta-analysis of the published literatures to determine the global self-declared prevalence of sensitive skin. Methods A systematic review of studies reporting the prevalence of sensitive skin was conducted searching electronic database of PubMed. Data were extracted and proportion meta-analyses were carried out to obtain the pooled prevalence. Results A total of 26 studies were included representing general population in 18 countries with 51 783 individuals. The pooled proportion of individuals with self-reported sensitive skin to some degrees was 71% [95% confidence interval (CI) 62%-81%] in the general population and 40% (95% CI 32%-47%) among individuals having very or moderately sensitive skin. Sensitive skin affected both women (45%, 95% CI 36%-55%) and men (33%, 95% CI 24%-42%), and women tended to be a risk factor with the development of sensitive skin compared to men (Risk Ratio=1.741, 95% CI 1.38-2.20). The corresponding estimates for prevalence were 38% (95% CI 25%-51%) among America, 35% (95% CI 32%-37%) among South America, 44% (95% CI 39%-50%) among Europe, and 31% (95% CI 16%-45%) among Asia, respectively. The pooled proportion of self-diagnosed facial sensitive skin to some degree was 64% (95% CI 49%-76%). For subjects responded as having very or moderately facial sensitive skin, the pooled proportion was 34% (95% CI 21%-46%). Conclusion Our meta-analysis based on published data showed that the global prevalence of self-declared sensitive skin to some degrees was 71% in the adult population, and 40% among individuals having very or moderately sensitive skin. However, the prevalence of sensitive skin was dependent on the diagnostic method and the prevalence might be overestimated in the questionnaire-based epidemiological studies.

Bariatric surgery is still at an early stage in China, but is now experiencing an explosive growth. A national registry system needs to be established to record and provide precise data.