Depressive disorder is one of the most commonly found non-communicable types of clinical disorder having serious impact, not only on the mental health status; but also on the health and socio-economic status of the concerned person. Though reason for depressive disorder is not conned to a particular reason, a wide range of chronic health issues, socio-demographic conditions, and even the family background have major impact on its occurrence. Patterns of intervention management in both adults and children involve psychotherapy with some specically designed self-help tools. In peculiar cases, depending upon the severity of depression, antidepressants can be used in pharmacotherapy. The current study meta- analysis is a systematic review analysis of depressive disorder causes in both adults and children through the validation of the assessment tools involved in measuring the severity and the types of interventions used by expert clinicians, to provide better cure of diseases.

INTRODUCTION:- Sepsis is a leading cause of morbidity and mortality internationally Early spotting and . interventions are essential to ensure better patient's outcome. Lactate concentration in septic patients is of particular prognostic value in predicting septic shock and mortality. AIM:- The present study was intended to evaluate the serum Lactate levels on the basis of severity rate in patients suffering of sepsis, severe sepsis and septic shock. MATERIAL & METHOD:- 100 patients diagnosed for sepsis were enrolled for the study and they were grouped as sepsis (n=30), severe sepsis (n=37)and septic shock (n=33). On the basis of survival rate serum Lactate levels in patients with sepsis were estimated in all the 3 categories of subjects according to the inclusion criteria. A p-Value of ≤0.05 were considered as statistically significant. RESULT:- In the present study when the lactate levels were evaluated among all the three categories, it was observed that the Lactate levels were found to be statistically significant (p-value <0.0001). Lactic acid evaluated on the basis of survival rate was also found to be statistically significant with the p-Value 0.015. CONCLUSION:- Lactic acid could be utilized as a reliable marker to assess prognosis at the initial phase of presentation because its initial evaluation shows good predictability in mortality prediction in sepsis patients.

Introduction: Lung cancer is the leading cause of cancer death globally. It is the malignant lung tumor with numerous histological variants. Due to the increasing number of tobacco smoking it is the major risk factor for lung cancer. Two main types of Lung cancer are Non-Small cell lung carcinoma (NSCLC) and Small cell lung carcinoma (SCLC). Folate is a water-soluble natural form of vitamin B9. It plays important role in homocysteine metabolism. Its decreased level may be associated with various cancers as is linked with altered DNA methylation and synthesis, and disruption of DNA repair activities. Aims: The present study was planned to evaluate the Serum Folate levels in patients diagnosed with lung carcinoma and to explore the association of increased serum folate levels with lung carcinoma patients. Materials & Methods: Fifty patients diagnosed for lung carcinoma were enrolled according to the inclusion criteria for the study. Fifty age and sex matched healthy individuals constituted the control group. Serum folate levels were estimated for all enrolled subjects. Results obtained were compared statistically among the lung carcinoma and healthy control groups. Results: Age of the study group and control group were comparable.