Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.

Synthetic organic chemists are beginning to exploit electrochemical methods in increasingly creative ways. This is leading to a surge in productivity that is only now starting to take advantage of the full-potential of electrochemistry for accessing new structures in novel, more efficient ways. In this perspective, we provide insight into the potential of electrochemistry as a synthetic tool gained through studies of both direct anodic oxidation reactions and more recent indirect methods, and highlight how the development of new electrochemical methods can expand the nature of synthetic problems our community can tackle.

The biological activity of natural products YM-254890 (YM) and FR900359 (FR) has led to significant interest in both their synthesis and the construction more simplified analogs. While the simplified analogs lose much of the potency of the natural products, they are of interest on their own right, and their synthesis has elucidated synthetic barriers to the family of molecules that need to be addressed if a scalable synthesis of YM and FR analogs are to be constructed. In the work described here, the synthetic route to simplified analogs of YM is examined and strategies for circumventing some of the challenges inherent to constructing the molecules forwarded.

Growth and Structure Refinement of CaSeO4·2 H2O.-Single crystals of the title compound are prepared from Na2SeO4 and CaCl2 by a controlled diffusion process with a diaphragm technique ( yielding "swallowtail" twinned crystals) followed by ultra-sound treatment in EtOH. The single crystal XRD data confirm that CaSeO4. times.2 H2O has a gypsum-type structure (monoclinic, I2/a, Z = 4). -(KRUEGER, R.-R.; ABRIEL, W.; Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 47 (1991Commun. 47 ( ) 9, 1958Commun. 47 ( -1959 AWHchemconsult, W-8000 Muenchen 70, Fed. Rep. Ger.; EN)