Foram examinadas fezes, coletadas após o sacrifício, de 9.150 cães e 674 gatos, capturados nas vias públicas do Município de São Paulo, SP (Brasil), visando o encontro de ovos e parásitos das famílias Ancylostomidae e Ascaridae. A coleta do material ocorreu durante os anos de 1980-1985. As seguintes taxas de infestação foram observadas: 59,83% dos cães e 22,26% dos gatos estiveram positivos para ovos de Ancylostoma sp., enquanto que 11,70% dos cães e 17,65% dos gatos apresentaram ovos de Toxocara sp.
Administration of olivacine, l,S-dimethyl-6H-pyrido[4,3-b] carbazole to mice inoculated with 1 6 , lo' and 102 leukaemic cells (L,,,,) produced significant survival in all treated groups which was not altered by association with the naturally occurring nucleoside deoxycytidine. Treatment with olivacine plus heterologous serum caused leucocytosis due to neutrophilia, lymphocytosis and monocytosis, as opposed to treatment with olivacine alone, which produced leucopenia due to neutropenia and lymphocytopenia.
MATERIAL AND METHODSOlivacine. This was obtained from the root bark of Aspidosperma nigricans or Aspidosperma olivaceum, extracted with ethanol and purified in the usual way for pyridocarbazole alkaloids (Gilbert, 1965).
Deoxycytidine.A dose of 50 mg/kg of 2-deoxycytidinium chloride (Merck, Darmstadt, FRG) was injected intraperitoneally on a daily regimen.Coadjuvant. Heterologous hyperimmune serum (horse), supplied by Dr P. Bueno (Instituto Biologico, Sao Paulo), was used; 0.2 mL ampules were applied subcutaneously at 5-day intervals.
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