We present the results for CAPRI Round 46, the third joint CASP‐CAPRI protein assembly prediction challenge. The Round comprised a total of 20 targets including 14 homo‐oligomers and 6 heterocomplexes. Eight of the homo‐oligomer targets and one heterodimer comprised proteins that could be readily modeled using templates from the Protein Data Bank, often available for the full assembly. The remaining 11 targets comprised 5 homodimers, 3 heterodimers, and two higher‐order assemblies. These were more difficult to model, as their prediction mainly involved “ab‐initio” docking of subunit models derived from distantly related templates. A total of ~30 CAPRI groups, including 9 automatic servers, submitted on average ~2000 models per target. About 17 groups participated in the CAPRI scoring rounds, offered for most targets, submitting ~170 models per target. The prediction performance, measured by the fraction of models of acceptable quality or higher submitted across all predictors groups, was very good to excellent for the nine easy targets. Poorer performance was achieved by predictors for the 11 difficult targets, with medium and high quality models submitted for only 3 of these targets. A similar performance “gap” was displayed by scorer groups, highlighting yet again the unmet challenge of modeling the conformational changes of the protein components that occur upon binding or that must be accounted for in template‐based modeling. Our analysis also indicates that residues in binding interfaces were less well predicted in this set of targets than in previous Rounds, providing useful insights for directions of future improvements.

The realization of efficient on‐chip microlasers with scalable fabrication, ultralow threshold, and stable single‐frequency operation is always desired for a wide range of miniaturized photonic systems. Herein, an effective way to fabricate nanostructures‐ whispering‐gallery‐mode (WGM) lasers by drop‐casting CdSe/CdS@Cd1−xZnxS core/buffer‐shell@graded‐shell nanoplatelets (NPLs) dispersion onto silica microspheres is presented. Benefiting from the excellent gain properties from the interface engineered core/hybrid shell NPLs and high‐quality factor WGM resonator from excellent optical field confinement, the proposed room‐temperature NPLs‐WGM microlasers show a record‐low lasing threshold of 3.26 µJ cm−2 under nanosecond laser pumping among all colloidal NPLs‐based lasing demonstrations. The presence of sharp discrete transverse electric‐ and magnetic‐mode spikes, the inversely proportional dependence of the free spectra range on microsphere sizes and the polarization anisotropy of laser output represent the first direct experimental evidence for NPLs‐WGM lasing nature, which is verified theoretically by the computed electric‐field distribution inside the microcavity. Remarkably, a stable single‐mode lasing output with an ultralow lasing threshold of 3.84 µJ cm−2 is achieved by the Vernier effect through evanescent field coupling. The results highlight the significance of interface engineering on the optimization of gain properties of heterostructured nanomaterials and shed light on developing future miniaturized tunable coherent light sources.

We present the results for CAPRI Round 50, the fourth joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of twelve targets, including six dimers, three trimers, and three higher-order oligomers. Four of these were easy targets, for which good structural templates were available either for the full assembly, or for the main interfaces (of the higher-order oligomers). Eight were

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