No abstract

Current state-of-the-art object objectors are fine-tuned from the off-the-shelf networks pretrained on large-scale classification dataset ImageNet, which incurs some additional problems: 1) The classification and detection have different degrees of sensitivity to translation, resulting in the learning objective bias; 2) The architecture is limited by the classification network, leading to the inconvenience of modification. To cope with these problems, training detectors from scratch is a feasible solution. However, the detectors trained from scratch generally perform worse than the pretrained ones, even suffer from the convergence issue in training. In this paper, we explore to train object detectors from scratch robustly. By analysing the previous work on optimization landscape, we find that one of the overlooked points in current trained-from-scratch detector is the BatchNorm. Resorting to the stable and predictable gradient brought by BatchNorm, detectors can be trained from scratch stably while keeping the favourable performance independent to the network architecture. Taking this advantage, we are able to explore various types of networks for object detection, without suffering from the poor convergence. By extensive experiments and analyses on downsampling factor, we propose the Root-ResNet backbone network, which makes full use of the information from original images. Our ScratchDet achieves the state-of-the-art accuracy on PASCAL VOC 2007, 2012 and MS COCO among all the train-from-scratch detectors and even performs better than several one-stage pretrained methods. Codes will be made publicly available at https: //github.com

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In-silico bitterant prediction received the considerable attention due to the expensive and laborious experimental-screening of the bitterant. In this work, we collect the fully experimental dataset containing 707 bitterants and 592 non-bitterants, which is distinct from the fully or partially hypothetical non-bitterant dataset used in the previous works. Based on this experimental dataset, we harness the consensus votes from the multiple machine-learning methods (e.g., deep learning etc.) combined with the molecular fingerprint to build the bitter/bitterless classification models with five-fold cross-validation, which are further inspected by the Y-randomization test and applicability domain analysis. One of the best consensus models affords the accuracy, precision, specificity, sensitivity, F1-score, and Matthews correlation coefficient (MCC) of 0.929, 0.918, 0.898, 0.954, 0.936, and 0.856 respectively on our test set. For the automatic prediction of bitterant, a graphic program “e-Bitter” is developed for the convenience of users via the simple mouse click. To our best knowledge, it is for the first time to adopt the consensus model for the bitterant prediction and develop the first free stand-alone software for the experimental food scientist.