Convenient and sensitive detection of biomolecules is of great significance to disease diagnosis. In this work, am etal-free photoinduced atom transfer radicalp olymerization (photoATRP) by ar eductive quenching pathway as an ovel strategy is appliedt oa chieve lung cancerD NA detection. Thiolated PNA is exploited to specifically recognize target DNA, and the initiator of photoATRP is linked to the electrode surface via phosphate-Zr 4 + -carboxylate. Under the excitation of blue light, the reductive quenching path-way is activatedw ith eosin Y( EY) as photoredox catalyst and N,N,N',N'',N'-pentamethyldiethylenetriamine (PMDETA) as electron donor,a nd numerous polymeric chains are formed. Under optimal conditions, the linear range of this strategy is from 0.1 pm to 10 nm (R 2 = 0.989)w ith al imit of detection (LOD) of 1.4 fm (14 zmol in 10 mL). Thev ariety of possible light sourcesf or photoATRP and simple operation endowt his biosensorw ith great potential for practical applications.[a] Dr.Supporting information and the ORCID identification number(s) for the author(s) of this articlecan be found under: https://doi.

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