Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours.

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BACKGROUND It is not known whether percutaneous radiofrequency ablation (PRFA) has the same treatment efficacy and fewer complications than laparoscopic resection in patients with small centrally located hepatocellular carcinoma (HCC). AIM To compare the effectiveness of PRFA with classical laparoscopic resection in patients with small HCC and document the safety parameters. METHODS In this retrospective study, 85 patients treated with hepatic resection (HR) and 90 PRFA-treated patients were enrolled in our hospital from July 2016 to July 2019. Treatment outcomes, including major complications and survival data, were evaluated. RESULTS The results showed that minor differences existed in the baseline characteristics between the patients in the two groups. PRFA significantly increased cumulative recurrence-free survival (hazard ratio 1.048, 95%CI: 0.265–3.268) and overall survival (hazard ratio 0.126, 95%CI: 0.025–0.973); PRFA had a lower rate of major complications than HR (7.78% vs 20.0%, P < 0.05), and hospital stay was shorter in the PRFA group than in the HR group (7.8 ± 0.2 d vs 9.5 ± 0.3 d, P < 0.001). CONCLUSION Based on the data obtained, we conclude that PRFA was superior to HR and may reduce complications and hospital stay in patients with small HCC.

To develop an effective technique for decreasing rotifer contamination in Spirulina platensis cultivation, the effects of 5‐fluoro‐2'‐deoxyuridine (FUdR; 0, 60, 110, 160, 210, and 260 μg/L) on the development, reproduction and population growth of the rotifer, Brachionus plicatilis and on the growth, photosynthetic properties and nutritional composition of S. platensis were investigated. The results showed that the negative effects of FUdR on the pre‐reproductive period, the number of total eggs per female and the egg hatching rate of rotifers were dose‐dependent. The egg hatching of rotifers was fully inhibited by exposure to 260 μg/L FUdR. The effects of FUdR on the biomass, maximum quantum yield (Fv/Fm), effective quantum yield (φPSII), amino acid content and fatty acid composition of S. platensis were not significant. Therefore, these results suggest that FUdR has excellent potential for controlling grazing zooplankton contamination in microalgal cultivation.