Speech perception is key to verbal communication. For people with hearing loss, the capability to recognize speech is restricted, particularly in a noisy environment or the situations without visual cues, such as lip-reading unavailable via phone call. This study aimed to understand the improvement of vocoded speech intelligibility in cochlear implant (CI) simulation through two potential methods: Speech Enhancement (SE) and Audiovisual Integration. A fully convolutional neural network (FCN) using an intelligibility-oriented objective function was recently proposed and proven to effectively facilitate the speech intelligibility as an advanced denoising SE approach. Furthermore, audiovisual integration is reported to supply better speech comprehension compared to audio-only information. An experiment was designed to test speech intelligibility using tonevocoded speech in CI simulation with a group of normal-hearing listeners. Experimental results confirmed the effectiveness of the FCN-based denoising SE and audiovisual integration on vocoded speech. Also, it positively recommended that these two methods could become a blended feature in a CI processor to improve the speech intelligibility for CI users under noisy conditions.

First-pass gadolinium-enhanced myocardial perfusion imaging at 3 Tesla is feasible. The Upslope ratio can differentiate ischemic from non-ischemic myocardium.

Autism Spectrum Disorder (ASD) is one of the Pervasive Developmental Disorders (PDDs). Significant deficits in the children with ASD include lack of social communication skills and cognitive dysfunction. This paper reviews and evaluates the influence of different kinds of Information and Computer Technology (ICT) applications that facilitate intervention and training for children with ASD. This paper also presents a novel design prototype, Facial Expression Wonderland (FEW), to train the children with ASD based on the progressive levels of training under a given background context. This prototype is designed to improve the ability of the ASD children in facial expression recognition.

Background Neuroimage literature of autism spectrum disorder (ASD) has a moderate-to-high risk of bias, partially because those combined with intellectual impairment (II) and/or minimally verbal (MV) status are generally ignored. We aimed to provide more comprehensive insights into white matter alterations of ASD, inclusive of individuals with II (ASD-II-Only) or MV expression (ASD-MV). Methods Sixty-five participants with ASD (ASD-Whole; 16.6 ± 5.9 years; comprising 34 intellectually able youth, ASD-IA, and 31 intellectually impaired youth, ASD-II, including 24 ASD-II-Only plus 7 ASD-MV) and 38 demographic-matched typically developing controls (TDC; 17.3 ± 5.6 years) were scanned in accelerated diffusion-weighted MRI. Fixel-based analysis was undertaken to investigate the categorical differences in fiber density (FD), fiber cross section (FC), and a combined index (FDC), and brain symptom/cognition associations. Results ASD-Whole had reduced FD in the anterior and posterior corpus callosum and left cerebellum Crus I, and smaller FDC in right cerebellum Crus II, compared to TDC. ASD-IA, relative to TDC, had no significant discrepancies, while ASD-II showed almost identical alterations to those from ASD-Whole vs. TDC. ASD-II-Only had greater FD/FDC in the isthmus splenium of callosum than ASD-MV. Autistic severity negatively correlated with FC in right Crus I. Nonverbal full-scale IQ positively correlated with FC/FDC in cerebellum VI. FD/FDC of the right dorsolateral prefrontal cortex showed a diagnosis-by-executive function interaction. Limitations We could not preclude the potential effects of age and sex from the ASD cohort, although statistical tests suggested that these factors were not influential. Our results could be confounded by variable psychiatric comorbidities and psychotropic medication uses in our ASD participants recruited from outpatient clinics, which is nevertheless closer to a real-world presentation of ASD. The outcomes related to ASD-MV were considered preliminaries due to the small sample size within this subgroup. Finally, our study design did not include intellectual impairment-only participants without ASD to disentangle the mixture of autistic and intellectual symptoms. Conclusions ASD-associated white matter alterations appear driven by individuals with II and potentially further by MV. Results suggest that changes in the corpus callosum and cerebellum are key for psychopathology and cognition associated with ASD. Our work highlights an essential to include understudied subpopulations on the spectrum in research.

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