Introduction:Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure.Aim:The synthesis of SPH of poly (acrylamide-co-acrylic acid) and its composites viz. Ac-Di-Sol and polyvinylpyrollidone (PVP) was carried out by solution polymerization.Materials and Methods:The SPH and SPH composites (SPHCs) were characterized by measurement of apparent density, porosity, swelling, mechanical strength, and scanning electron microscopy (SEM) studies.Results:FTIR studies confirmed the existence of acrylamide and acrylic acid in SPH. In distilled water SPH showed tremendous increase in equilibrium swelling capacity with conventional SPH as compared to its SPHCs of Ac-Di-Sol and PVP due to the increased in physical cross-linking network, respectively. The presence of Ac-Di-Sol and PVP in SPHCs increased the mechanical strength as compared to conventional SPH which is suitable for gastric retention. SEM pictures clearly indicated the formation of interconnected pores and capillary channels.Conclusion:The amount and type of polymers used affect almost all the characterization parameters of SPHs, and hence, depending upon the applications perspective such polymers could be used in drug delivery systems, successfully.

Shah et al.: Stability-indicating Analytical Method for Ezetimibe and Glimepiride Stability-indicating reversed-phase high-performance liquid chromatography method was developed and validated for the simultaneous estimation of ezetimibe and glimepiride. Chromatographic separation was achieved with a Shimadzu's high performance liquid chromatograph and PhenomenexL1 analytical C18 column with a mobile phase of acetonitrile:ammonium acetate buffer (30 mM):methanol (50:45:5 %, v/v/v). The flow rate was set at 1.5 ml/min and the detection wavelength was 232 nm. Quality by design approach was employed for optimization of method parameters like proportion of mobile phase, concentration of buffer and a model highlighting the design space was generated. This developed chromatographic method gave well resolved symmetric peaks. Ezetimibe and glimepiride were eluted at 6.7 and 4.4 min, respectively. This method was validated according to International Conference on Harmonisation Q2(R1) guideline. The method was linear in range of 50-400 µg/ml for ezetimibe and 5-40 µg/ml for glimepiride with r 2 =0.9999 and 0.9996, respectively. The sample recoveries were in good agreement with the respective label claim, which suggested non-interference from formulation additives in the estimation. Forced degradation studies were carried out and the stressed samples were analysed using the developed methods.

Background: Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure. The literature survey reflects the preparation of SPHs and its composite, but its application as an excipient in a drug delivery system is not well focused. Aim: Efforts were made to develop fast disintegrating tablets of Glipizide using superporous hydrogel particles (SPHPs) as a wicking agent, which act as a superdisintegrant to decrease disintegration time. Materials and Methods: The SPH of poly (acrylamide-co-acrylic acid) was prepared by solution polymerization and characterized. Prepared tablets were evaluated for concerned parameters. Formulation optimization was carried out using 3 2 full factorial design and analysis of variance. Results: Scanning electron microscopy pictures clearly confirmed the superporous structure of hydrogel. Batch F 4 containing 4% w/w of SPH of poly (acrylamide-co-acrylic acid) as a superdisintegrant showed extremely fast wicking effect and lesser disintegration time compared with other potential superdisintegrants. Drug release was good compared with conventional immediate release marketed product. Conclusion: It can be concluded that SPHPs can be used as a potential superdisintegrant in tablet formulation.