Preparation and characterization of superporous hydrogel based on different polymers

Abstract

Introduction:Superporous hydrogel (SPH) swells very rapidly in a shorter period of time to an equilibrium size and contains highly porous structure.Aim:The synthesis of SPH of poly (acrylamide-co-acrylic acid) and its composites viz. Ac-Di-Sol and polyvinylpyrollidone (PVP) was carried out by solution polymerization.Materials and Methods:The SPH and SPH composites (SPHCs) were characterized by measurement of apparent density, porosity, swelling, mechanical strength, and scanning electron microscopy (SEM) studies.Results:FTIR studies confirmed the existence of acrylamide and acrylic acid in SPH. In distilled water SPH showed tremendous increase in equilibrium swelling capacity with conventional SPH as compared to its SPHCs of Ac-Di-Sol and PVP due to the increased in physical cross-linking network, respectively. The presence of Ac-Di-Sol and PVP in SPHCs increased the mechanical strength as compared to conventional SPH which is suitable for gastric retention. SEM pictures clearly indicated the formation of interconnected pores and capillary channels.Conclusion:The amount and type of polymers used affect almost all the characterization parameters of SPHs, and hence, depending upon the applications perspective such polymers could be used in drug delivery systems, successfully.

Fabrication of Xanthan gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Evaluating Skin Wound Healing Efficacy

“…Hydrogels are cross-linked, three dimensional, hydrophilic polymeric networks with the ability to hold large amount of water within its porous structure (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009). However, they do not dissolve in water when brought into contact with water (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009).…”

“…Hydrogels are cross-linked, three dimensional, hydrophilic polymeric networks with the ability to hold large amount of water within its porous structure (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009). However, they do not dissolve in water when brought into contact with water (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009). The water holding capacity of hydrogels is induced by the presence of hydrophilic groups, such as hydroxyl, carboxyl, amide, and sulfonic groups distributed along the backbone of polymer chain; whereas the cross-links are formed by either covalent bonds, electrostatic or dipole-dipole interactions (Rithe, 2014;El-Sherbiny and Yacoub, 2013;Chavda, 2012;& Pal, 2009.Hydrogels have achieved considerable interest in the last few decades due to their wide range of clinical and biomedical applications ranging from drug delivery (Qui and Park, 2001), tissue engineering (El-Sherbiny and Yacoub, 2013;Vlierberghe, 2011&Hoffman, 2002,regenerative medicine (El-Sherbiny and Yacoub, 2013), contact lenses (Walther, 2011& Zhang, 2011), wound dressings (El-Kased, 2017Gupta, 2011& Lu, 2010, soil water retention (Wei and Durian, 2013) to disposable diapers (Colón, 2011).…”

Super Porous Hydrogel: A Promising Gastroretentive Drug Delivery System

“…Density of superporous hydrogel determined by solvent displacement method. [55] Actually it was a apparent density. …”

Preparation of bacterial cellulose based hydrogels and their viscoelastic behavior

“…CMC can absorb large amount of water, can swell in form of hydrogel and has good physical property inform of viscoelasticity [8]. PVP is also one of the synthetic biodegradable polymer which has already recorded its application in the area of pharmaceutical and also in medicines because of its high absorption capacity, complex forming abilities and high mechanical property [6,7,9,10].…”

“…This hydrogel has porous structure, can expand and have greater water absorption capacity and elasticity [5,6]. For designing any polymeric material to have its application in biomedical fields, it's necessary to improve its functional properties.…”