Objective: The present study investigated the effects of different dose levels of Zinc oxide Nanoparticles (ZnO NPs) on the liver and kidney tissues in albino male mice. Methadology: ZnO NPs was administrated as a daily oral dose of (150, 350 mg/kg body weight) gavage for 2 weeks. Eighteen male mices were used by dividing them into three groups. Result: Histopathological examination of kidney and hepatic tissues treated with ZnO NPs showed toxicity changes compared with control group. Conclusion:This study demonstrated the ability of ZnO NPs to affect on kidney and liver tissues. Recommendation: More study needed to know the effect of different doses of nanoparticles on human health.

Breast cancer is caused by malignant cells in the breast tissue and is still one of the main medical concerns, especially for women, with socio-economic significance. Oxidative stress plays an important role in the development, growth, and invasion of breast cancer. Glutathione and Catalase deficiency contributes to oxidative stress, which plays a key role in aging and pathogenesis of many diseases, one of which is cancer. The aim of the study is to determine CAT activity and GSH concentration as an antioxidant in women having breast cancer and compared it with healthy control women. A serum of (40) breast cancer patients has been taken to estimate the levels of CAT and GSH. All studied patient's samples were female with a mean age (47.88±10.92) years old. The result of the study revealed that serum CAT activity in breast cancer patients was 4.17×10-4 nmol/L (range 0-20.83×10-4) which was far much lower than that of the control (median 12.5×10-4, range 0-125.63×10-4 nmol/L). Whereas, GSH concentration in patients was 6350 mmol/L (range 850-16450 mmol/L) which appeared significantly lower than the control groups (7950 mmol/L; range 7350-15150 mmol/L).

Breast cancer, the most frequent disease in women worldwide, represents a significant public health concern on a global scale. Breast cancer was the most frequent type of cancer among Iraqi women in 2018, accounting for the highest percentage of malignant tumors in women. Breast cancer is a set of physiological and molecular heterogeneous diseases that begin in the breast. Advanced breast cancer with distant organ metastases is considered incurable with current therapies. Aside from new treatment improvements, the next global challenge in breast cancer care is equal worldwide access to therapeutic advances. The incidence of breast cancer continues to rise in every part of the world. Despite advances in its identification and treatment, which have resulted in lower mortality rates, it appears vital to seek out new therapeutic approaches, predictive and prognostic indicators. The article provides a literature review of breast carcinoma, a condition that affects women worldwide. As a result, women should be aware of the disease's course, the importance of regular screenings for early detection of breast cancer, and the best treatment options.

Background & Objective: Breast cancer (BC) is the most prevalent disease among women around the world, considered the world's leading cause of death (15% of the total cancer deaths) in women in 2018. β-catenin is a multifunctional protein located in the cytoplasm and/or nucleus of the cell. Several studies suggested that β-catenin expression plays a critical role in cancer invasion and metastasis. This research sought to examine β-catenin expression in breast cancer and its associations with clinico-pathological features (such as histopathological types, grade, and invasion depth of tumor as well as lymph node involvement) and breast cancer patient survival. Methods: The study was performed in the period from 1 January to July 2019 on 40 female breast cancer patients. The control group involved 40 healthy females with no history of cancer. Tissue blocks from histologically confirmed patient and control subjects were fixed in formalin and embedded in paraffin . β-catenin was evaluated by immunohistochemistry (IHC). Results: The immunohistochemical study of the subcellular localization of β-catenin demonstrated that 75% of the patients showed 1-3 score for β- catenin compared to only 27.5% of controls who had such score, with a highly significant difference. Conclusions: The use of β-catenin IHC markers can be effective throughout the treatment of progressive BC.

Objective: Across section analytic study was carried out to identify the effect of folic acid on birth of pregnant women at Al-Najaf government and to determine the statistical significant differences between folic acid and some variables. Methodology: A purposive sample of (1054) of pregnant women was selected of Al-Zahra maturity pediatric hospital, data was collected through the interview of women. Question forma was designed and contained (3) parts demographic variables, reproductive variables and variables related to effect of folic acid. Results: Descriptive and in fevential statistical procedures were used to analyze the data. The result of the study revealed that the age of women was ranged between (21-25) years and the highest percentage of them house wife (640). The result indicate that a significant association between takes folic acid and congenital anomalies. The present study was revealed that the percent of normal deliveries (38.9%), while in cesarean sections (58.8%). In normal deliveries the percent of congenital anomalies was (1.2%), and the percent of congenital anomalies in cesarean sections was (0.9%). Conclusion: The study concluded that there was a significant difference between taking folic acid and congenital anomalies. Recommendation: According to these finding it is recommended to emphasize on prenatal care early as possible and education improve health services presented to the mother during pregnancy that the health team must take the role in reducing the incidence of congenital anomalies by taking folic acid.