Matrix metalloproteinases (MMPs) have been linked to modulating healing during the production of tertiary dentin, as well as the liberation of physiologically active molecules and the control of developmental processes. Although efforts to protect dentin have mostly centered on preventing these proteases from doing their jobs, their role is actually much more intricate and crucial for dentin healing than anticipated. The role of MMPs as bioactive dentin matrix components involved in dentin production, repair, and regeneration is examined in the current review. The mechanical characteristics of dentin, especially those of reparative and reactionary dentin, and the established functions of MMPs in dentin production are given particular attention. Because they are essential parts of the dentin matrix, MMPs should be regarded as leading applicants for dentin regeneration.

Since the development of ruby laser by Maiman in 1960 & application of laser for endodontics by Weichman in 1971, a variety of papers on potential applications for lasers in endodontics have been published. Lasers have been a significant advancement in the field of endodontics. Be it effective cleaning, root canal treatment, surgery etc. The lateral accessory canals and anatomical complexities have been a restraint in root canal procedure, for such cases lasers have been introduced to simplify the process & have good clinical results. As there has been a boon in the improvement of laser techniques, many latest lasers having a broad array of characteristics is accessible and can also be helpful in several areas related to dentistry. When compared with conventional techniques, laser treatments has been proven to be more advantageous. The purpose of this article is to summarize laser applications in endodontics, including their use in pulp diagnosis, dentinal hypersensitivity, pulp capping and pulpotomy, sterilization of root canals, root canal shaping & obturation & apicectomy. This article reviews the role of lasers in endodontics since the early 1970s & summarizes what future may hold for endodontics. With the potential availability of many new laser wavelengths and modes, much interest is developing in this promising field.

Nanoscience is a planned blend of nanotechnologies/nanoparticles used in healthcare to discover novel treatment strategies for human infections. N anotechnology is used in many aspects of our daily lives, including medical science. Nanostructures are employed in dental advances, diagnosis and treatment [2]. When compared to traditional materials, Nanoparticles was shown to have significantly superior adhesive plus surface properties. Nanotechnology’s practical implementation in endodontics has allows for new study in this domain.