Background Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation. Results After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (p < 0.001) and Actinobacteria (p < 0.001) and a significant increase in Bacteroidetes (p < 0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (p < 0.05), gas (p=0.035), and abdominal pain (p=0.015) as well as significant improvements in stool consistency (p < 0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (p=0.107). The supplement was safe and well tolerated. Conclusions The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.

Summary Incorporation of D‐amphetamine into the hair of a black‐pigmented guinea‐pig was measured by a 14C‐tracer method. D‐Amphetamine administered intraperitoneally was found to be incorporated into the hair, and part of the radioactivity was found in isolated melanin. The findings are in conformity with the concept that D‐amphetamine gains access to melanocytes through the arteriovenous or lymphatic circulation, enters melanosomes, interacts with the melanosomal protein and melanin, and resides ultimately in the pigment granules in the hair fibre. The findings suggest a pathway which may influence the biological activity of this and related drugs.

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Eight weeks of oral supplementation positively impacted ADMs resulting in protection against UVR-induced skin damage and improvements in facial skin attributes and characteristics.

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