A reduced SjvO2 value was observed more frequently in patients with preexisting diabetes mellitus or stroke during normothermic cardiopulmonary bypass. It is possible that cerebral circulation during normothermic bypass is altered in patients with risk factors for cerebrovascular disorder.

Hepatic sinusoidal endothelial cells (SECs) are pivotal in the regulation of sinusoidal blood flow. This study showed that SEC function might be impaired during and after cardiopulmonary bypass, irrespective of the temperature management.

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P Pu ur rp po os se e: : To assess and compare the effects of normothermic and mild hypothermic cardiopulmonary bypass (CPB) on hepatosplanchnic oxygenation.M Me et th ho od ds s: : We studied 14 patients scheduled for elective coronary artery bypass graft surgery who underwent normothermic (>35°C; group I, n=7) or mild hypothermic (32°C; group II, n=7) CPB. After induction of anesthesia, a hepatic venous catheter was inserted into the right hepatic vein to monitor hepatic venous oxygen saturation (ShvO 2 ) and hepatosplanchnic blood flow by a constant infusion technique that uses indocyanine green.R Re es su ul lt ts s: : The ShvO 2 decreased from a baseline value in both groups during CPB and was significantly lower at ten minutes and 60 min after the onset of CPB in group I (39.5 ± 16.2% and 40.1 ± 9.8%, respectively) than in group II (61.1 ± 16.2% and 61.0 ± 17.9%, respectively; P <0.05). During CPB, the hepatosplanchnic oxygen extraction ratio was significantly higher in group I than in group II (44.0 ± 7.2% vs 28.7 ± 13.1%; P <0.05).C Co on nc cl lu us si io on n: : Hepatosplanchnic oxygenation was better preserved during mild hypothermic CPB than during normothermic CPB.