Background Very premature infants are at high risk of developing a symptomatic postnatal cytomegalovirus (CMV) disease, such as CMV‐related sepsis‐like syndrome (CMV‐SLS). To address the limited data regarding its clinical features, a nationwide survey of CMV‐SLS was conducted. Methods A questionnaire regarding CMV status and the clinical outcomes of CMV‐SLS was sent to centers with reported cases of CMV‐SLS. Results Twelve CMV‐SLS cases, nine confirmed and three probable cases, were reported during the 3‐year survey period. The median gestational age and birthweight were 25 weeks and 547 g, respectively. At disease onset, the median age was 49 days, and the corrected age was 31 weeks. Untreated breast milk was given in four cases (33%), whereas frozen breast milk was given in nine (75%). No specific symptoms and laboratory data regarding CMV‐SLS were found. Conclusions Very premature infants developed CMV‐SLS after 1 month of age. There are no symptoms and signs specific for the diagnosis of CMV‐SLS, so CMV‐SLS should be considered as a differential diagnosis for premature infants who have unexplained sepsis‐like symptoms during the convalescent phase.

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Patients with poor-grade subarachnoid hemorrhage have a very poor prognosis, especially those with cardiopulmonary arrest and/or bilateral dilated pupils. Therapeutic indications for patients with poor-grade subarachnoid hemorrhage vary depending on the institution; however, we perform clipping or coil embolization in these patients with very poor-grade subarachnoid hemorrhage if their vital signs are stable at the time of admission. In this study, we summarize the outcomes of 31 patients with poor-grade subarachnoid hemorrhage seen between January 2015 and April 2017. Among the 31 patients, 13 patients had cardiopulmonary arrest at the time of admission and/or prehospital, and 15 patients had bilateral dilated pupils. Among these 13 patients with cardiopulmonary arrest, seven patients underwent clipping or coil embolization because their vital signs could be stabilized. The functional outcomes of these seven patients were very poor: mRS 1 (1 patient), mRS 4 (1 patient), and mRS 5 (5 patients); however, all of these patients survived 30 days after the subarachnoid hemorrhage onset. Meanwhile, the other nine patients with unstable vital signs and who could therefore not undergo clipping or coil embolization died within 30 days after the subarachnoid hemorrhage onset.In conclusion, although the functional outcomes of patients with poor grade subarachnoid hemorrhage and cardiopulmonary arrest were very poor, a minority of these patients had good functional outcomes.

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