Injured neurons in the mammalian central nervous system (CNS) possess a very limited ability to regenerate axons under physiological conditions. This is in marked contrast with peripheral axons, which can regrow and establish functional connections even after the formation of lesions. The absence of regeneration in the CNS is caused by an inhibitory influence of the environment of the injured axons and the lack of intrinsic factors that enable regeneration in the peripheral nervous system (PNS) (He & Jin, 2016;Hilton & Bradke, 2017;Liu et al., 2011). Fundamentally similar processes are thought to be important for developmental axon growth and axonal

No abstract