The current study is an exploration to examine older Japanese individuals' motivations for travel. The study employed an open-ended survey and in-depth interviews in order to gain insight into the creation of human relationships through tourism. Our results show that tourism is perceived as offering extraordinary opportunities to meet new people, and to form and develop new relationships by Japanese older individuals, who experience fewer opportunities to interact with other people in their everyday lives compared to individuals in younger generations. In particular, distinct features of tourism settings, such as liminality and touristic communitas, allow older tourists to express themselves more freely by escaping from their existing relationships as well as from many social norms, hierarchies, and prohibitions.

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In order to understand the mechanism for maintaining life of animals based on the search of dynamics of bio-molecules, I have developed several sensitive and selective methods for their quantiˆcation. Using the methods of derivatization with the developed benzofurazan ‰uorogenic reagents (4-‰uoro-7-nitro-2,1,3-benzoxadiazole (NBD F), ammonium 7-‰uoro-2,1,3-benzoxadiazole 4-sulfonate (SBD F) and etc.) followed by high-performance liquid chromatography (HPLC)-‰uorescence detection, a certain kind of biological and clinical importances was demonstrated of chiral bio-molecules (D-amino acids, D-lactic acid and so on), peptides and proteins. The proposed method (derivati-zation with SBD F, isolation of the ‰uorescent proteins by two-dimensional HPLC, enzymatic digestion and identiˆca-tion of the altered proteins by HPLC mass spectrometry (MS)/MS with database-searching algorithm) for proteomics studies revieled the changed proteins in the islets of Langerhans of the dexamethazone-induced diabetic rats. An importance of catecholamine metabolism on the blood pressure regulation was also suggested by the method of HPLC chemiluminescence detection of catecholamines and their 3-O-methylmetabolites. A newˆeldnewˆeld of Analytical Chemistry, i.e., Bio-Analytical Chemistry, was also proposed.

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