A 28-year-old woman experienced severe headache and right homonymous hemianopia after receiving high-dose infliximab for Crohn's disease. Computed tomography showed hemorrhagic infarction in the left temporal and parietal lobes. An angiogram revealed left transverse to sigmoid sinus occlusion and a stagnated Labbe vein. The patient was treated surgically and achieved a good outcome. Inflammatory bowel diseases are known to accompany venous and arterial thrombosis in 1%-2% of cases. Recently, infliximab has been suggested to increase this possibility. A case of Crohn's disease presenting with cerebral sinus thrombosis in the remission period during long-term/high-dose use of infliximab is presented. In addition, infliximabassociated thrombosis cases were reviewed.

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Background Meningiomas are the most common benign intracranial tumors, and commonly comprise high-vascularizing but slow-growing tumors. On the other hand, meningiomas arising from the ventricular system are of rare occurrence, and spontaneous hemorrhage is an infrequent event. Case presentation We describe here the rare clinical manifestations of a 28-year-old female with acute intracranial hemorrhage located in the trigone of the lateral ventricle who was initially thought to have suffered an acute cerebrovascular accident, but was subsequently confirmed to have a benign intraventricular meningioma. To clarify the clinical features of such a rare course of meningioma, we also present a short literature review of acute intracranial hemorrhage caused by intraventricular meningioma. Conclusions Ventricular meningioma presenting with hemorrhage such as acute stroke is a rare event, but recognition of such a pathogenesis is important. Although further accumulation of clinical data is needed, we suggest that early surgery should be undertaken in patients with lateral ventricular meningioma, even if it is not so large or asymptomatic.

Cutaneous squamous cell carcinoma(cSCC)normally spreads to locations close to the primary lesion. We describe an extremely rare case of brain metastasis from cSCC in a 47-year-old female who had undergone removal of lower leg cSCC (T2N0M0) 2 years previously. She was admitted to our hospital with dizziness. Contrast-enhanced computed tomography imaging showed a cerebellar lesion with contrast effect. We performed surgical removal and histological examination revealed that the lesion was metastasis from lower leg cSCC. She was given radiotherapy for the residual tumor(39 Gy) . After the operation and radiotherapy, magnetic resonance imaging showed significant reduction in the size of the residual tumor and the posttreatment course was uneventful. No standard treatment strategy for brain metastasis from cSCC has been established. Therefore, further investigations are needed to establish an effective treatment for these tumors.