Research objective was to study influence of L-arginin on endothelial system indexes in patients with bronchial asthma. 82 patients with bronchial asthma have been examined. 2 groups have been formed. Patients of the basic group in addition to standard basic therapy received the nitrogen oxide donator - L-arginin. The comparison group only received a basic therapy. The condition of endothelial system was estimated before and after ten-day course of treatment based on the following indicators: changes in the level of the main stable metabolites of nitrogen oxide in plasma of blood and in a condensate of exhaled air as well as that of L-arginin in plasma.

The aim of the study was to study the effect of L-arginine on the content of certain interleukins in the exhaled air condensate (CVC) in patients with bronchial asthma. 52 patients with a persistent asthma of a moderate course were examined. Two groups were formed. Patients of the main group (26), in addition to the standard basic therapy, received a nitric oxide donor -L-arginine. The comparison group (26) received only basic therapy. In patients of both groups before and after treatment, certain parameters of the immune system (IL-4, TNF-α) were measured in CMV. The initial data in patients of both groups were characterized by an increase in IL-4 and TNF-α in KVV compared with the group of healthy individuals. The content of IL-4 and TNF-α in KVB against the background of L-arginine significantly decreased during the control period. Changes in these parameters in the control group were not so pronounced and were unreliable. The inclusion of L-arginine in the baseline therapy contributed to an earlier and significant decrease in the content of the studied interleukins. Sphenopalatine Ganglion Block a Jack of all Trades Block 13Copyright: ©2018 Gharaei et al. Materials and MethodsWe examined 52 patients aged 18 to 55 years (38.5 ± 4.2 years) with persistent asthma of moderate course, with duration of disease on average 15 + 2.3 years, and 15 healthy volunteers. By the method of random sampling, two groups comparable in age and sex were formed. Patients of the main group (n = 26), in addition to standard basic therapy (GINA, 2007) received a nitric oxide donor -L-arginine. The drug (100 ml of a 4.2% solution, Tivortin, YURIYAFARM, Ukraine) was injected iv by drop, once a day, for 10 days. The comparison group (n = 26) received only basic therapy. In patients of both groups, the parameters of the immune system were evaluated before and after treatment. In IVC, the content of interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) was determined. The collection of KVV was carried out by the method of GI Sidorenko et al. (1980) modified by us. The determination of cytokines (IL-4, TNF-α) in CMC was performed by the method of enzyme immunoassay. Reagent kits for immunoenzymatic analysis of human cytokines from Vector-Best (Novosibirsk) were used. The received data are processed on a personal computer in the Microsoft Excel software environment using the built-in "Analysis package", which is specially designed for solving statistical problems.