Pancreaticobiliary maljunction is a congenital anomaly in which the junction between the pancreatic duct and the common bile duct is located outside the sphincter of Oddi. It is well known that pancreaticobiliary maljunction is frequently associated with carcinoma of the biliary tract. We report a case of metachronous cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction and cystic dilatation of common bile duct in a 68-year-old Tunisian woman who underwent a cholecystectomy for acute cholecystitis. The pancreatic tumor was an adenosquamous carcinoma. Pancreaticobiliary maljunction allows for pancreatobiliary or biliopancreatic reflux which may induce biliary tract carcinoma. Few cases of multifocal cancer associated with this anomaly have been reported. The association with pancreatic carcinoma remains rare. Close attention should be given to both the biliary tract system and pancreas during the long-term follow-up of patients with pancreaticobiliary maljunction, especially after they have undergone a choledochojejunostomy.

Xanthogranulomatous cholecystitis is an uncommon variant of chronic cholecystitis, characterized by marked thickening of the gallbladder wall and dense local adhesions that may be confused with a malignant process. In this paper, the authors report a new case of xanthogranulomatous cholecystitis in a 63-year-old female patient that was misdiagnosed per-operatively as gallbladder cancer and treated with extensive excision. The common imaging techniques are not always able to differentiate xanthogranulomatous cholecystitis from gallbladder cancer and the final diagnosis is usually established by histological examination of the resected specimen. This entity should be kept in mind in difficult cholecystectomy cases. [J Interdiscipl Histopathol 2013; 1(5.000): 280-285

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