The most recent technologies for sperm sorting involve microfluidics. However, the most important question whether their use is of any advantage in terms of laboratory and clinical IVF/ICSI outcomes still remains controversy. In this study, we aimed to investigate whether a microfluidic sperm sorting device (Fertile Plus ® ) has a positive add-on effect on laboratory and clinical outcomes. Sibling oocytes of 81 patients were assigned to two sperm sorting groups including swim up and Fertile Plus ® . All embryos were cultured until day 5/6. Fertilisation, embryo quality and blastocyst development were assessed as primary outcomes among 81 patients; clinical pregnancy, implantation and live birth rates were analysed as secondary outcomes as a subgroup analysis due to transfer cancellations. No statistically significant differences were found between groups in terms of all outcomes analysed in laboratory and clinical terms (p > .05 for all). The results of this study suggest that sorting spermatozoa through Fertile chip does not improve laboratory outcomes significantly and does not seem to have a positive contribution to clinical outcomes. K E Y W O R D Schip, implantation, intracytoplasmic sperm injection, microfluidic, sibling

Essential thrombocythemia (ET) is an entity of classic Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), characterized by thrombocytosis with megakaryocytic hyperplasia and thrombocytes are increased with abnormal functions. Discovery of the protein tyrosine kinase JAK2 V617F allele contributed to better understanding of the pathogenetic mechanisms of MPNs. Acquired single point mutation in the JAK2 V617F was determined approximately 50-60 % of patients with ET. In this study we aimed to investigate the relationship between JAK2 V617F gene mutation, hematologic, biochemical markers and the complications in the ET patients. A total of 268 patients diagnosed with ET and 219 of those studied for JAK2 gene mutation were followed at the hematology clinics of three major hospitals between 2008 and 2013 were screened retrospectively. Laboratory, clinical and hematologic parameters were compared for JAK2 V617F positive and JAK2 V617F negative patients with ET. 102 (46 %) patients were positive with the JAK2 V617F mutation. The complications were observed in 61 (28 %) patients and 38 (62 %) of them had JAK2 V617F mutation. The levels of white blood cells, neutrophil, basophil, red blood cells, hemoglobin, hematocrit, mean platelet volume, thrombocytes, eosinophil; urea, creatinine were significantly different in patients with the JAK2 V617F mutation (P < 0.05). Presence of the JAK2 V617F mutation supports the diagnosis of ET. It would be useful to investigate the JAK2 V617F mutation and the hematologic and biochemical markers at diagnosis with respect to consider the risk of developing complications and to take the precautions against these complications.

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Araştırmanın amacı ilkokula başlama yaşının 5. Sınıftaki öğrencilerin benlik saygısı ve sosyal uyum düzeyleri ile ilişkisini incelmektir. Ayrıca bazı demografik değişkenlerin (cinsiyet, kardeş sayısı, anne baba eğitim düzeyi, anne-baba birliktelik durumu, anaokuluna devam durumu ve ilkokulda öğretmen değişikliği yaşayıp yaşamama durumu) sosyal uyum ve benlik saygısı arasındaki ilişkiler incelenmiştir. Bunun için İstanbul ili Kartal ilçesindeki 26 Ortaokulda 436 5. sınıf öğrencisine Walker-McCannell Okula Uyum ve Sosyal Yeterlik Ölçeği, Coopersmith Özsaygı Envanteri Kısa Formu ile amaca uygun olarak düzenlenmiş Demografik Bilgi Formu uygulanmıştır. Verilerin analizinde Bağımsız Örneklem T Testi, Pearson Korelasyon Analizi ve Tek Yönlü Varyans Analizi (ANOVA) yapılmıştır. Araştırmadan elde edilen bulgulara göre, öğrencilerin benlik saygılarının ve sosyal uyum düzeylerinin, okula başlama yaşına göre anlamlı bir şekilde farklılaşmadığı saptanmıştır. Ayrıca, kız öğrencilerin benlik saygılarının erkek öğrencilerden anlamlı bir şekilde daha yüksek olduğu; anne-babası birlikte yaşayan öğrencilerin benlik saygılarının anne-babası ayrı olanlardan daha yüksek olduğu saptanmıştır.