Background: The novel corona virus has been identified as the cause of respiratory illness in Wuhan, Hubei province, China, since December, 2019. It has spread almost all the countries and areas (212) in world. Due to distinct demographics of infection, variation of case fatality and clinical presentation in different countries, the knowledge of demographic distribution and analysis of clinical profile from this study would help for patient management of COVID-19 till the invention of specific drug and vaccines. We aimed to analyze the clinical profile of fist 100 cases of COVID-19 admitted in a teaching hospital. Methods: In this observational study, RT-PCR confirmed first 100 hospitalized COVID-19 cases, admitted in Mugda Medical College Hospital were included. With well informed consent, a structured questionnaire was fulfilled during the time of hospital stay. Data were analyzed with clinical outcome, hospital stay, clinical staging and comorbidity of admitted patient from 20th March to 10th April. Results: Among the total participants, male were predominate (59%). Age groups were ranging from 9 to 80 years and mean age was 43 years. Common symptoms were fever (91%), cough (33%), dyspnea (41%), sore throat (12%), diarrhea (12%) and myalgia (2%). Mild cases (53%) were common, followed by moderate (31%), severe (13%) and critical (3%). Average hospital stay was 11 days. Common comorbidities were diabetes mellitus (21%), hypertension (17%), chronic kidney disease (11%), bronchial asthma (8%), stroke (3%) and ischaemic heart disease (2%). Conclusion: Distinct demographic presentation with age variability, clinical presentation with variable fatality in different countries may help the further steps taken by the policymaker of low resource country for the prevention of infection and management of COVID-19. Birdem Med J 2020; 10, COVID Supplement: 18-22

Aim: This study was aimed to evaluate the association between serumD-dimer, serum Ferritin with disease severity in patents havingCOVID-19. Methods:Total 80 confirmed COVID-19 patients were enrolled in this cross sectional study. Samples were assessed by positive SARSCoV- 2 by RT-PCR testing and were collected from two tertiary Hospitals(IbnSina Medical College Hospital and Ibrahim Cardiac Hospital and Research Institute).We also performed CT findings of COVID patients with or without pulmonary involvement. COVIDpositive patients were divided into two groups (Group 1 and Group2) according to lungs involvement confirmed by CT-scan. In this analysis, several variables such as gender, age, D-dimer and serum ferritin were taken. Results: The Mean of D-dimer in Group-1 subjects was 4.26±3.60mg/L and in Group-2, this was 0.59±1.08mg/L. So D-dimer level was significantly raised in COVIDpneumonic patient (P value = <0.001). The mean of ferritin(554.65±515.841)ng/ml for pneumonic patient was also highly significant than the mean(133.70±109.22)ng/ml of COVID without pneumonia. Conclusion:D-dimer and S. ferritin were elevated in patients with COVID-19. These two reliable biomarkers are correlate with the disease severity and useful for better management of COVIDpositive patients. Bangladesh Journal of Medical Science Vol.20(5) 2021 p.166-170