Interstitial lung disease (ILD) are an extensive group of rare entities, with an advanced or chronic evolution and with different degrees of inflammation and/or fibrosis. 1 It includes a heterogeneous group of manifestations, which differ in etiology, pathogenesis, clinical course, prognosis and therapeutic options. The authors described a clinical case of a 52-year-old woman treated with different cycles of antibiotic therapy for pneumonia and development of severe type II of respiratory failure, refractory to the established therapy. Due to the presented evolution and imaging characteristics the diagnosis of ILD was conjectured. The diagnosis, although carried out post-mortem, through the analysis of lung tissue, revealed to be a case of alveolar proteinosis, most likely associated with a myelodysplastic syndrome.
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