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The estrogenic monomer bisphenol-A (BPA) is an endocrine-disrupting chemical used in the production of epoxy resins, plastic food and beverage containers, leading to ubiquitous human exposure. Environmentally relevant doses of BPA have profound effects on mice endocrine pancreas. It increases pancreatic insulin content and favors postprandial hyperinsulinemia and insulin resistance in male mice. Skeletal muscle plays a crucial role in maintaining systemic glucose metabolism. In the present study, we investigated the possible effects of BPA on insulin-signaling molecules and glucose oxidation in skeletal muscle of male rat. Adult male Wistar albino rats were divided into three groups. Group I: control (vehicle treated) and groups II and III were administered with BPA orally (20 and 200 mg/kg bw/day, respectively). Although there was no change in the levels of insulin receptor (IR), Akt (protein kinase B) and glucose transporter-4 (GLUT4) messenger RNA, BPA significantly decreased the IR, Akt and GLUT4 protein levels (both plasma membrane and cytosolic fraction) of the gastrocnemius muscle. There was an increase in serum insulin and decrease in serum testosterone levels but fasting blood glucose level remained unaltered. In conclusion, BPA has adverse effects on phosphorylation of Akt, GLUT4 translocation and (14)C-glucose oxidation.

Iodine retention in three types of iodised salt viz., powdered salt, white crystal and brown crystal salt was estimated at an interval of 15 days following commonly practised storage methods i.e., glass jar with lid, plastic jar with lid, earthernware pot with lid, cut open salt packet and salt pack as it is. Highest percent retention of iodine irrespective of type of salt was noticed in intact salt packet (97.19%). The iodine retention was above 80% in other methods--88.41% retention in cut open salt packet, 84.72% in glass jar, 82.86% in earthern pot and 80.85% in plastic jar. Powdered salt had maximum iodine retention (91.16%) followed by brown crystal salt (84.24%) and white crystal salt (76.71%). Even though the iodine content was found to decrease during storage, the powdered salt and brown crystal salt had iodine in the recommended level. On the contrary, white crystal salt contained only half (7 ppm) that recommended at the retail level (15 ppm).

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