2013
DOI: 10.1177/0960327112470273
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Effect of bisphenol-A on insulin signal transduction and glucose oxidation in skeletal muscle of adult male albino rat

Abstract: The estrogenic monomer bisphenol-A (BPA) is an endocrine-disrupting chemical used in the production of epoxy resins, plastic food and beverage containers, leading to ubiquitous human exposure. Environmentally relevant doses of BPA have profound effects on mice endocrine pancreas. It increases pancreatic insulin content and favors postprandial hyperinsulinemia and insulin resistance in male mice. Skeletal muscle plays a crucial role in maintaining systemic glucose metabolism. In the present study, we investigat… Show more

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Cited by 51 publications
(27 citation statements)
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“…In addition, it can also interfere with insulin transduction of target cells, inducing insulin resistance [11]. Recently, two important factors related to BPA have been highlighted for its relationship with insulin resistance, namely oxidative stress and adiponectin production [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, it can also interfere with insulin transduction of target cells, inducing insulin resistance [11]. Recently, two important factors related to BPA have been highlighted for its relationship with insulin resistance, namely oxidative stress and adiponectin production [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…They reported an impaired insulin and glucose tolerance together with a reduced activation of Akt signaling pathway in the gastrocnemius muscle both in BPA-treated pregnant mice and male offspring, thus suggesting a reduced peripheral insulin sensitivity. In addition to this study, Indumathi and collaborators [43] found that BPA exposure to adult male rats induced downregulation of insulin receptors, Akt and Akt phosphorylation and the glucose transporter GLUT-4 protein expression both in membrane and cytosol. These data worked together with a reduction in glucose oxidation in the gastroecnemius muscle and an increase in circulating insulin levels, contributed to the development of insulin resistance in these animals.…”
Section: Bpa Affects Glucose Utilization In Musclesmentioning
confidence: 53%
“…For example, TCDD [7174], organotins [75,76], and BPA [48,51,64,77,78] differentially affect insulin levels and action depending on the experimental model. Acute TCDD exposure induces a wasting syndrome characterized by weight loss, adipose derangements, hyperlipidemia, ectopic lipid deposition, and hypoinsulinemia [79].…”
Section: Context-dependent MDC Actionmentioning
confidence: 99%