Introduction: The study of novel Schiff bases and their metal complexes have achieved enormous attention of inorganic as well as medicinal chemists. Objective: To study the structural elucidation and antimicrobial screening of 3-formylchromone and 3-aminoquinoline based Schiff base and their metal complexes. Methods: Cu(II) and Co(II) complexes of 3-((quinolino-3-ylimino) methyl)-4H-chromen-4-one ligand were synthesized and characterized by elemental analysis, molar conductivity measurement, infrared, UV-Visible, 1H NMR spectral studies, thermogravimetric analysis, and powder X-ray diffraction studies. Results: Antibacterial activity of synthesized compounds were screened against Klebsiella pneumoniae, Staphylococcus aureus, and Proteus vulgaris, and antifungal activity was screened against fungi Candida albicans and Aspergillus niger. Schiff base ligand and their Cu(II) and Co(II) complexes revealed significant antibacterial and antifungal activity against tested strains. Octahedral geometry of metal complexes was proven by analytical, physical, and spectral data. Conclusion: In this present work, novel Schiff base 3-((quinolino-3-ylimino) methyl)-4H-chromen-4-one and its Cu(II) and Co(II) complexes revealed promising antibacterial and antifungal activities.

Synthesis of Ni(II) and Fe(III) complexes with Schiff base 6-methyl-3-((quinolin-3-ylimno) methyl)-4H-chromen-4-one obtained from 3-formyl-6methylchromone and 3-aminoquinoline.Schiff base and its complexes were characterized by analytical data, elemental analysis, molar conductance, thermogravimetric analysis. The structural investigation performed by UV-Vis, IR and 1 HNMR spectral techniques. Interpretation of elemental analysis shown 2:1 molar ratio of Schiff base with metal complexes. Molar conductance values indicate neutral nature of metal complexes. Antimicrobial activity studied at different concentration (MIC method) by disc diffusion technique. Schiff base and the metal complexes found to be significant antibacterial and antifungal agents.