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An efficient and convenient method is described for the synthesis of 3-aryl-2-(4,5-dimethyl-2H-1,2,3-triazol-2-yl)-1,8-naphthyridines (4) from α-acetylacetaldoxime 3-aryl-1,8-naphthyridin-2-ylhydrazones (3) in the presence of acetic anhydride and DMF using basic alumina as solid support under microwave irradiation.

Synthesis of new series of chromen-2-one-1,2,3-Triazoles (6a-6j) was reported using the help of key methods such as [3+2]-cycloaddition and ultrasound. All compounds were further evaluated for their in vitro anticancer activity profile in three human cancer cell lines MCF-7(breast), A-549 (lungs), and HeLa (cervical). Among all, three compounds namely 6c, 6f, and 6j showed the most promising activity against three lines, when compared with the etoposide.

A simple and efficient protocol for the synthesis of 5‐aryl‐2‐(2‐substituted‐1,8‐naphthyridin‐3‐yl)‐thiazolo[3,2‐b][1,2,4]triazoles (4) is achieved by cyclocondensation of 3‐(2‐substituted‐1,8‐naphthyridin‐3‐yl)‐1,2,4‐triazoles (3) with α‐halogenoketones in anhyd. methanol under microwave irradiation. The products are obtained in good yields and in a state of high purity.

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