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phosphorylation and elevation of Bim. The retrospectively analyze clinical data of 45 cases of NSCLC patients showed the median progression-free survival (PFS) in osimertinib plus aspirin group patients were significantly longer than those in osimertinib alone group patients. Conclusion:Aspirin, a generally safe and inexpensive drug, has synergistic effects with osimertinib via modulation of Bim-dependent apoptosis in osimertinib-resistant NSCLC cell lines and xenografts. It may be an effective strategy for overcoming acquired resistance to osimertinib and prolonging survival in patients with NSCLC.

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We studied the effect of putrefactive decomposition of sheep hooves on the cellular composition, physical and chemical properties of blood, as well as on the biochemical composition of its serum. In the production conditions of the sheep-breeding complex, orthopedic medical examination and identification of sheep with putrefactive decay of the hooves were carried out. Subsequently, blood samples were collected from 10 sick sheep and 10 clinically healthy animals for general clinical analysis and biochemical analysis of their serum. The selected blood samples were analyzed on the haematological automatic analyser "Abacus vet 10" and the semi-automatic biochemical analyser "Stat fax 300". In the biochemical composition of blood serum, putrefactive decay of hooves increased the concentration of total protein by 7.94%, total bilirubin by 22.08%, urea by 75.18%, and reduced the concentration of glucose by 17.88% relative to clinically healthy sheep. At the same time, the activity of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and creatine kinase in the blood serum of sheep with putrefactive hoof decay exceeded similar indicators in clinically healthy sheep by 9.65%, 9.16%, 13.70%, and 19.90%, respectively. In addition, the concentration of sodium, potassium, calcium, phosphorus and magnesium in the blood serum of sheep with putrefactive decay of hooves was by 15.44%, 9.64%, 3.49%, 25.35% and 9.78% less than in the blood serum of clinically healthy sheep.