I. Introduction II. Normal vs. Extremes of Growth A. Defining CTS B. Endocrinology of CTS III. Endocrinology of Bone Growth and Maturation IV. Sex Steroid Action on Bone Growth and Maturation V. Height Prediction A. Skeletal maturity or BA B. Computed assisted skeletal age-scoring systems C. Accuracy of height prediction D. New prediction equations in constitutionally tall children VI. Treatment of CTS: General Concepts VII. Treatment of Constitutionally Tall Boys A. T treatment modalities B. Height reduction C. Effects on gonadal function D. Other clinical effects VIII. Estrogen Treatment in Tall Girls A. Estrogen treatment modalities B. Height reduction C. Effects on gonadal function D. Other adverse effects IX. Alternative Treatment Modalities and Future Research X. Conclusions and Recommendations