Background-Eradication ofThere was a significant diVerence (p < 0.001) in the proportion of patients in whom eradication was successful between LAC and LCM when compared with LAM, but no significant diVerence (p = 0.15) between LAM and OAM. Metronidazole resistance before treatment was identified as a significant prognostic factor with regard to eradication of H pylori. The regimens which contained metronidazole were significantly less eVective than those without metronidazole in the presence of pretreatment resistant H pylori. There was no diVerence among the treatment groups with regard to the incidence and severity of adverse events reported. Conclusions-All four treatment regimens were safe and eVective in eradicating H pylori in the patient population studied. LAC was the most eYcacious treatment in patients with pretreatment metronidazole resistant H pylori, and was significantly better than LAM and OAM in this group of patients. (Gut 1997; 41: 735-739)

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