No abstract

The present work deals with the study of the ethanolic extract of fruits of Sechium edule for cardioprotective activity. Cardioprotective activity of the ethanolic extract of fruits of S. edule was determined by the administration of isoproterenol (60 mg/kg, s.c) for two days. Pretreatment with S. edule (200 mg/kg, p.o and 100 mg/kg, p.o) for 28 days in significantly (p<0.01) reduce the levels of serum transaminases, alkaline phosphates, lactate dehydrogenase, creatinine kinase, total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and increase the levels of HDL-cholesterol. Histopathological studies of the hearts of isoproterenol treated rats have shown infiltration of inflammatory cells and continuity in muscle fiber was lacking suggesting an irreversible cell injury. Animals treated with ethanolic extract of S. edule showed less degenerative changes compared to isoproterenoltreated animals. Article Info

No abstract

Introduction: Accidental spinal anomalies of the spinal dura mater are the source of cerebrospinal fluid (CSF) leakage. Typically, dura abnormalities are identified in 3 percent of endoscopic lumbar discectomy cases. Objective: The purpose of the current research was to evaluate the results of autologous dura replacement versus collagen-based grafts in individuals with dura deformities. Methods: The Institute of Neurosurgery at Liaquat National Hospital Karachi undertook this randomized evaluation to identify the most effective therapy for dura mater defects. Employing non-probability random selection, 82 cases among both sexes were selected. Participants were divided randomly into two subgroups i.e. Group 1A received an autologous graft for dura restoration, whereas Group 2B received a semi-synthetic dura replacement. A skilled surgeon led a medical team of six people who completed the entire process. Results: The operation duration for semi-synthetic collagen was significantly reduced. There was a 40 minute variation in total time spent by the two groups. Autologous grafts showed ideal tightness and better flexibility and fair workability on the other hand semi-synthetic collagen showed better tightness and workability and ideal flexibility. Postoperative hospital stays were seen to be 26 + 2.5 hours in Group 1A whereas they were 23 + 2.5 hours for Group B. Conclusion: According to the aforementioned findings, an accessible, secure, and efficient substitution for an autologous graft for dura restoration in dura abnormalities is the use of a semi-synthetic collagen substitute. Keywords: semi-synthetic collagen substitute, cerebrospinal fluid, dura abnormalities, autologous graft.