[1] Nobeoka Thrust in Kyushu, southwest Japan, was investigated to understand the relationship between the seismogenic out-of-sequence thrust (OST) and fluid flow in accretionary prisms. The Nobeoka Thrust is a fossilized OST, being active at seismogenic depth. The hanging wall exhibits a penetrative plastic deformation, while a brittle, cataclastic mélange-like occurrence characterizes the footwall, although both of them have same shale and sandstone-dominant protolith. Vitrinite reflectance analyses indicate that the maximum temperatures of the hanging wall and footwall are approximately 320 and 250°C, respectively. This thermal gap across the thrust corresponds to 8.6-14.4 km of displacement assuming a 28-47°C/km geothermal gradient. The brittle damage zone of the thrust is asymmetric: only 2 m for hanging wall side and 100 m for footwall. Three types of mineral veins, quartz, and carbonate are well developed, especially in the damaged footwall: the tension crack-filling vein, the fault-filling vein, and postmélange one. The first is harmonious with fabric, perpendicular to the P surface. Fluid inclusion geothermobarometry indicates the P-T of fluid in the intensively damaged zone of the footwall is $300°C, 230 -250 MPa, higher than that from vitrinite reflectance, which suggests that hydrothermal fluid flow is associated with deformation. The same type vein in the lowest portion of the footwall-damaged zone includes a much lower P-T fluid. This difference suggests that continuous underplating caused the damaged zone to propagate downward with cooling and shallowing, which differs from faults characterized by shear localization and might be unique to aquiferous OST in accretionary complexes. Citation: Kondo, H., G. Kimura, H. Masago, K. Ohmori-Ikehara, Y. Kitamura, E. Ikesawa, A. Sakaguchi, A. Yamaguchi, and S. Okamoto (2005), Deformation and fluid flow of a major out-of-sequence thrust located at seismogenic depth in an accretionary complex: Nobeoka Thrust in the Shimanto Belt, Kyushu, Japan, Tectonics, 24, TC6008,