Introduction Increased physical activity and functional ability are the goals of total knee replacement surgery. Therefore, adequate rehabilitation is required for the recovery of patients after discharge from hospital following total knee arthroplasty (TKA). This systematic literature review aimed to evaluate the effectiveness of home telerehabilitation in patients who underwent TKA. Methods Studies published in the English language between 2000 and 2014 were retrieved from Embase, PubMed, and Cochrane databases using relevant search strategies. Two researchers independently reviewed the studies as per the Cochrane methodology for systematic literature review. We considered telerehabilitation sessions as those that were conducted by experienced physiotherapists, using videoconferencing to patients' homes via an internet connection. The outcomes assessed included: knee movement (knee extension and flexion); quadriceps muscle strength; functional assessment (the timed up-and-go test); and assessment of pain, stiffness, and functional capacity using the Western Ontario and McMaster Universities Osteoarthritis Index and visual analogue scale for pain. Results In total, 160 potentially relevant studies were screened. Following the screening of studies as abstracts and full-text publications, six primary publications (four randomized controlled trials, one non-randomized controlled trial, and one single-arm trial) were included in the review. Patients experienced high levels of satisfaction with the use of telerehabilitation alone. There was no significant difference in change in active knee extension and flexion in the home telerehabilitation group as compared to the control group (mean difference (MD) -0.52, 95% CI -1.39 to 0.35, p = 0.24 and MD 1.14, 95% CI -0.61 to 2.89, p = 0.20, respectively). The patients in the home telerehabilitation group showed improvement in physical activity and functional status similar to patients in the conventional therapy group. Discussion The evidence from this systematic literature review demonstrated that telerehabilitation is a practical alternative to conventional face-to-face rehabilitation therapy in patients who underwent TKA.

modeled for a time horizon of 35-40 years or for a lifetime to demonstrate cost effectiveness. CONCLUSIONS: This analysis shows the range, variability, and methods used for calculation of ICER values for these high budget impact drugs and provides lessons for executives and policy makers.

The lifetime functional disabilities associated with cancer have received little attention in the literature. This study determines the dynamic changes of different physical functional disabilities over time and their total duration after cancer diagnosis to understand their potential long-term care needs. Methods: 395,330 patients with pathologically verified cancer registered in the National PRM7 Role of teleRehabilitation in Patients following total knee aRthRoPlasty: eviDence fRoM systeMatic liteRatuRe Review

the Total SGRQ score (r= 0.73) and Symptoms (r= 0.62); Activity (r= 0.55), Impact (r= 0.72) subscales; the modified MRC Dyspnoea scale (r= 0.54), FACIT-F (r= -0.66); HADS Anxiety (r= 0.53) and Depression (r= 0.54). The MEMSI also demonstrated good overall fit to the Rasch model (Chi-squared 26.6; df 20; p= 0.26) and distribution of item scores. ConClusions: The final MEMSI contains 10-item and is a reliable, valid, unidimensional self-reported outcome measure of early morning symptoms for people with COPD. It is quick and simple making it suitable for use in research and practice. Further work is underway to determine the minimal clinical important difference.

A415people with psoriasis. Methods: We used the Taiwan's National Health Insurance Research Database to conduct a nationwide population-based cohort study to assess the risk of incident CKD and ESRD in people with psoriasis and to further evaluate the respective risk estimates in those with mild and severe psoriasis based on treatment patterns. Results: A total of 4,633 psoriatic patients and 922,534 nonpsoriatic controls were included. Severe psoriasis, but not mild psoriasis, was an independent risk factor of incident CKD and ESRD (adjusted hazard ratio being 1.90 (95% confidence interval 1.33-2.70) and 2.97 (95% confidence interval 1.72-5.11), respectively) after adjustment for potential confounders including age, gender, comorbidities, and used of nonsteroidal anti-inflammatory drugs (NSAIDs). Severe psoriasis remained an independent risk factor of incident CKD and ESRD after various sensitivity analyses after adjusting for the presence of osteoarthritis and/or rheumatoid arthritis, use of methotrexate and/or cyclosporine, and chronic use of NSAIDs for at least 2 months. Psoriatic arthritis was an effect modifier for CKD and ESRD. ConClusions: The associations of severe psoriasis with CKD and ESRD should be recognized. Assessment of renal function and avoidance of long-term use of nephrotoxic drugs shall be implemented in the integrative care for patients with severe psoriasis.