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Young rats were maintained on diets differing in fat content. The determination of certain parameters of the lipid and the energy metabolism in the liver showed that a high-fat diet resulted in a reduction of the stationary level of acetyl CoA, an increase in the concentration of acetoacetate and a reduction of the adenosine triphosphate content and the so-called energy charge. In case of intact respiratory chain phosphorylation, the oxygen consumption of the respective liver homogenates was simultaneously increased. The results obtained with a high-fat diet are indicative of the attainment of a metabolic state which seems to be typical of metabolic regulations in growing rats subjected to anabolic lipometabolism.

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