: Diabetes Mellitus is characterized as a set of metabolic disorders that have hyperglycemia in common, caused by defects in the action and / or in the secretion of insulin. It is a noncommunicable disease, considered one of the main public health problems and of widespread growth in the world, a difficult condition to treat and expensive to manage. Metabolic surgery is a safe treatment, regulated by the Federal Council of Medicine and indicated for the treatment of people with a Body Mass Index above 30, who are not successful in controlling pathologies associated with obesity, especially type 2 diabetes. The general objective of this study is to understand through a literature review the main impacts of metabolic surgery on the remission of type 2 Diabetes Mellitus. The present study is an exploratory and descriptive study carried out through a literature review. Data were collected through searches in virtual health databases, at the Virtual Health Library - VHL, Latin American and Caribbean Health Sciences Information System, LILACS, National Library of Medicine - MEDLINE, Scielo, database USP, PUBMED theses and books. Metabolic surgery proves to be an effective treatment to achieve not only sustained weight loss, but also a significant metabolic improvement that goes beyond mere weight loss. Metabolic surgery provides a more effective way to achieve long-term weight loss in obese individuals, increasing overall survival in this group of patients. Obese DM2 patients have a good chance of achieving long-term remission of DM2 after bariatric / metabolic surgery. Therefore, it concludes that such procedure is effective in the treatment of the disease and other diseases associated with obesity.

Objective: Epilepsy is a common neurodegenerative disorder characterized by spontaneous and repeated attacks of convulsions. It requires immediate pharmacotherapy to prevent its progression to status epilepticus. However, most of the anticonvulsant drugs are poorly water-soluble and demonstrate the delayed onset of action. Thus there is a need to improve its solubility for the better pharmaceutical profile. The objective of the present investigation was to enhance the solubility of lamotrigine incorporating soya lecithin as a phospholipid carrier by solid dispersion technique Methods: Solid dispersions of lamotrigine were prepared with soya lecithin by the solvent method. The effect of concentration of phospholipid and solvents on aqueous solubility and dissolution profile of lamotrigine was analyzed.Results: Ethanol increased lamotrigine solubility with soya lecithin in ratio 5:1. X-ray diffraction and scanning electron micrograph indicated a smaller crystallite size of lamotrigine with fairly uniform size distribution in the lamotrigine-soya lecithin solid dispersion. The resultant solid dispersion also significantly delayed the onset of clonic convulsion (875.8 s) as compared to control (85.5 s) and offered complete protection (100%) against the pentylenetetrazole induced seizures in the rat as compared to control (33.33%). Also, solid dispersion with maximum drug content (77.68%) and dissolution rate (91.40%) was formulated as an orodispersible tablet and characterized for its pharmaceutical properties. Conclusion:It can be concluded that the solid dispersion of lamotrigine incorporated with soya lecithin demonstrated enhanced solubility and dissolution rate may have potential clinical application. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

No abstract