Although intra-abdominal lymphangioma and mesenteric cysts are rare benign tumours, they have to be considered in the differential diagnosis of abdominal pain. Differentiation of these lesions is important, because lymphangiomas may follow a proliferative and invasive course. From 1979 to 1993 four patients with intra-abdominal cystic lymphangiomas and two with mesenteric cysts underwent operations in our surgical department. Five of these six patients had abdominal symptoms, ranging from unspecific abdominal pain to acute clinical abdomen. In all cases surgical enucleation or resection and histological classification were necessary before final diagnosis was possible.

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The Bird's Nest inferior vena caval filter (Cook, Bloomington, Ind) has been approved for clinical use since 1989. The authors report two cases of cephalic migration of the filter. Both cases of migration occurred in association with a massive thromboembolism after placement of the filter. It appears that a massive thromboembolism can cause this filter to migrate cephalad. The authors suggest that there is potential for nonsurgical management of the migrated filter.

Objectives Peripheral ulcerative keratitis (PUK) is a severe corneal condition associated with uncontrolled rheumatoid arthritis (RA). Tocilizumab (TCZ) is used to control RA, however, episodes of paradoxical ocular inflammation have been reported in TCZ-treated patients. We report a case series of PUK in TCZ-treated RA patients with ophthalmological and systemic findings and discuss the potential underlying mechanisms. Methods Four patients (6 eyes), aged 47–62 years were included. At the onset of PUK, the median duration of RA was 13 years (3–13), and the median treatment with TCZ was 9 months (3–14). Two patients had active disease (DAS 28 > 3.2) and the disease was controlled in 2 patients (DAS 28 ≤ 3.2). Results TCZ was initially replaced by another immunomodulatory treatment in all patients and later reintroduced in 2 patients without PUK recurrence. Corneal inflammation was controlled in all cases with local and systemic treatments, with severe visual loss in one eye. Conclusion To summarize, PUK may occur in patients with long standing RA after a switch to TCZ and can be interpreted, depending on the context, as insufficient efficacy or a paradoxical manifestation. These cases highlight the urgent need for reliable biomarkers of the efficacy/paradoxical reactions for biologics.