The haematology of Nigerian local puppies experimentally infected with the Federe strain of Trypanosoma brucei was studied in a total of six 9-weeks old puppies born to two local bitches. Four were randomly selected and inoculated with about 0.8 x 10 6 of T .brucei subcutaneously and the remaining two served as the uninfected control. The parasitaemia was monitored daily using wet mount microscopy. The packed cell volume (PCV), red blood cell (RBC) counts, total and differential white blood cell (WBC) counts and rates of both red blood cell and white blood cell loss per day and per parasitaemia log equivalent value(LEV) were monitored twice in a week . Parasitaemia was detected in the infected group four days after infection which was followed by an acute disease course, though with low fatality rate in the dogs.