Background: Infection with viral agents causes upregulation of cytokines such as Tumor Necrosis Factor-alpha (TNF-α), which is considered an important mediator of inflammation. TNF-α has been associated with a poor prognosis in patients with the severe acute respiratory syndrome (SARS). Patients and methods: This study included 66 mild COVID-19 patients with confirmed COVID-19 infection and 22 healthy people as a control group, these study subjects were randomly selected irrespective of the age group and both genders were included, 1 ml blood sample was collected for performing serum TNF-α levels test, Reagents of EIAab is located at East Lake Hi-Tech Development Zone, Wuhan China. Human tumor necrosis factor ELISA kit TNF-α serum levels immunoassay test catalog number E0133h. Results: This study reveals that serum TNF-α levels for mild COVID-19 patients and healthy control people were non-significant with a p-value of 0.1191 between the two groups.Conclusion: the serum TNF-α level is not a significant biomarker for diagnosis or prognosis of mild COVID-19 patients (Outpatients and patients under home observation), while other studies reported patients with COVID-19 demonstrated significantly elevated levels of TNF-𝛼 upon admission to hospitals.

Background: the identification of a simple and effective prognosticator is crucial for high lightening and treating the potentially critical patients, to reduce the mortality rate, Serum CRP is a simple and effective prognosticator which casts light on potentially critical patients, Serum CRP has a predictive value of COVID-19. Patients and methods: This study included 328 out-hospitalized patients with confirmed COVID-19 infection, these study subjects were randomly selected irrespective of the age group and both genders were included, Assay procedure as manufactory instructions and Reagents of Cromatest Linear chemicals S.L.U.Barcelona Spain turbidimetric method is used. Results: Female gender was more frequent (n=192, 58.5%) than Male gender (n=136, 41.5%). This study reveals a high level of CRP in 296 patients (90.2%) with a sensitivity of 90.2%, which is divided into two groups the first have CRP levels 5-100 (56.1%) and the second group has CRP levels more than 100 (34.1%), the high-level CRP was a significant biomarker for COVID-19 diagnosis or prognosis in out-hospitalized patients (Outpatients and patients under home observation), with a p-value is p is < .00001which less than 0.05. Conclusion: CRP levels were positively correlated with mild COVID-19 infection of lung lesions with a sensitivity of 90.2%. CRP levels could reflect disease severity and should be used as a key indicator for disease monitoring.