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Objectives To evaluate the hepatoprotective activity of fractions of Jasminum elongatum methanolic extract against acetaminophen-induced hepatic damage. Materials and Methods Fractions obtained from methanolic extract of J. elongatum (petroleum ether, chloroform and hydroalcoholic) were investigated for hepatoprotective activity. Doses of 100 mg/kg and 200 mg/kg of different fractions were administered for 7 days, and acetaminophen toxicity was induced on the eighth day. After 24 hr of toxicity induction, biochemical markers and histological alterations were measured to determine the amount of hepatoprotection. Results The chloroform and hydroalcoholic fractions showed a significant decrease in biochemical parameters when compared to the toxic group, which was confirmed by histopathological changes and antioxidant parameters. Conclusion The results of this study revealed that the chloroform and hydroalcoholic fraction of J. elongatum have significant hepatoprotective activity against acetaminophen-induced toxicity.

Reportedly, plants such as Cassia angustifolia and Tridax procumbens are used in Siddha medical systems to treat various diseases. Using a chick embryo wound model developed as part of the study, the presented research aimed to determine the wound-healing efficacy of methanol and aqueous extracts of the flowers and leaves. The experimental results show that the methanol extract exhibited good dose-dependent curative efficacy. In the chick embryo chorioallantoic membrane excision wound model, the 300g concentration of polyherbal methanol extract increased wound concentration by 50% compared to the negative control model. Compared to single plants and control groups, the results of the polyherbal Preparation were positive. The extract was also a reliable alternative to animal models for the preliminary screening compounds with wound-healing potential.

Introduction: Erythroxylum monogynum belonging to family Erythroxylaceae is commonly found in southern parts of India. Traditionally, leaves of the plant possess high medicinal value and known for the treatment of diabetes, jaundice and to kill intestinal worms, which are scientifically reported. However, no elaborative pharmacognostic study of leaves has been performed yet. Objective: To pharmacognostically standardize the leaves by studying anato mical characters of transversal section and powdered leaves. Material and methods: Leaf samples were studied by macroscopy, microscopy, physicochemical and preliminary phyto chemical analysis as recommended by WHO. Results: Externally the leaves are elliptic -lanceolate, alternate, base attenuate, apex obtuse and entire margin. Internally it shows the presence of paracytic stomata confined to lower epidermis, conjoint, collateral arc shaped vascular bundles encircled by sclerenchyma, lignified fibers and xylem vessels with spiral thickening. Powder microscopy revealed the presence of epidermis with papillae, phytochemical and physicochemical of powdered drug proved useful to differentiate the powdered drug material. Conclusion: The establishment of botanical features of leaf material will be useful in identification and standardization of Erythroxylum monogyum in obtaining quality formulations.

Background: Cancer still remains a disease of concern with various side effects of synthetic chemotherapeutic agents. Hence, there is a continued need to develop safer therapies with fewer side effects. Erythroxylum species is a widely available source of various phytoconstituents, especially terpenoids. Objective: To carry out the docking studies of a few terpenoids on validated targets like EGFR, VEGFR, CDK, and tubulin protein which are overexpressed in many types of cancers, and to estimate the pharmacokinetic and drug-likeness properties of these molecules using in silico techniques. Materials: Protein structures were retrieved from Protein Data Bank, and the terpenoids were docked on each of the protein targets using Autodock 4.2. SwissADME was used to predict the pharmacokinetic and drug-likeness properties Results: Compounds show good binding affinity and inhibition constant for all targets except for tubulin, where few ligands could bind. They exhibit an excellent pharmacokinetic profile, and no significant violations in drug-likeness parameters were observed. Conclusion: Compound 2 was found to be the most active agent against VEGFR, CDK, and tubulin, whereas compound 7 was most effective at EGFR. These compounds can be continued for further studies.