Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

Syed, Sabeena Hussain; Namdeo, Ajay G.

doi:10.1016/s2221-1691(13)60172-0

Cited by 11 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, overdose of APAP will saturate the conjugation pathways of GSH and cause depletion of cellular GSH. It is well-known that the mechanism of metabolism of APAP was subsequently leads to reduced capacity of GSH to detoxify NAPQI and thus the increased level of NAPQI oxidizes tissue macromolecules, such as lipids or protein thiols, and alters the homeostasis of calcium after depleting glutathione which leads to oxidative damage and thus enhances cellular injuries and organ dysfunction, including renal damage [10]. In correlations, a study suggests that APAP overdose induces renal oxidative stress elucidated when lipid peroxidation rise and antioxidant enzymes levels decrease [11].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IOSR

View full text Add to dashboard Cite

The ameliorative effects of Moringa oleifera L. (M. oleifera) is well known to modulate and enhance several immune parameters. The present study investigates the efficacy of the aqueous extract leaves of the M. oleifera on prevention of acetaminophen (APAP) induced acute renal injury in Wistar rats. Thirty albino rats were arranged randomly into 5 groups of 5 rats. Group 2 served as intoxicated group and received APAP (200 mg/kg). Group 3, 4 and 5 received APAP (200 mg/kg) + M. oleifera at doses 250, 500 and 1000 mg/kg, respectively. While first group was served as control rats group. All treatment was given orally to animals for 14 days. Clinical signs were observed regularly and rats were sacrificed and bloods and tissue samples were collected for biochemical and histological analysis. Biochemical results showed that M. oleifera protected the toxic remarks caused by APAP when decrease the elevated levels of serum creatinine, blood urea, cholesterol and lipids, while increases the plasma levels of total protein and albumin. Also, the nephroprotective effects of extracts was strongly correlated with decreased damage of the renal cellular damage, as evidenced by histological findings when compared to the group treated with APAP. Our findings provide evidence to demonstrate that aqueous extract of M. oleifera has a potent nephroprotective effect on APAP-induced kidney injury in rats. It is proposed that the action of plant is through its antioxidative and its ability to restoration or promoting glutathione (GSH) through decrease in the biotransformation of APAP via cytochrome P-450 pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IOSR

View full text Add to dashboard Cite

show abstract

“…Entre os contaminantes mais consumidos no mundo estão os fármacos, merecendo destaque o paracetamol, esta droga que, quando ingerida em doses elevadas pode causar danos ao fígado em humanos e animais. Sendo assim, é importante propor tratamentos que destroem a sua presença em matrizes de água (SYED; NAMDEO, 2013). Em estudo realizado por Jedrychowski et al (2011), foi observado que mesmo em doses pequenas de paracetamol, quando ingeridas por grávidas, pode haver uma contribuição para o surgimento de processos alérgicos em seus filhos.…”

Section: Introductionunclassified

Degradação do contaminante emergente paracetamol empregando processos oxidativos avançados

Napoleão

Zaidan

Salgado

et al. 2015

REGET

View full text Add to dashboard Cite

Uma classe de poluentes tem sido investigada por pesquisadores de todo o mundo, estes são os contaminantes emergentes, que são considerados persistente e refratário. Estes compostos estão presentes em diferentes matrizes ambientais em baixas concentrações que requerem tratamentos alternativos de polimento capazes de promover a degradação destes poluentes, uma vez que os tratamentos convencionais não são capazes de removê-los. Este estudo avaliou a degradação do paracetamol utilizando processos oxidativos avançados (ação UV/H2O2 e foto-Fenton). Os resultados mostraram que o processo ação UV / H2O2 foi mais eficiente conseguindo promover a degradação de 99% do paracetamol, o que é corroborado pela estatística que mostraram que as experiências isentas da adição de ferro (UV / H2O2) foram os mais eficientes na degradação do paracetamol em solução aquosa solução. A metodologia para a identificação através de cromatografia foi validado de acordo exigência das agências existentes (INMETRO e ANVISA), assegurando a confiabilidade dos resultados.

show abstract

Advances in chemistry and bioactivity of the genus Erythroxylum

Tian

Wang

et al. 2022

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Erythroxylum P. Browne is the largest and most representative genus of Erythroxylaceae family. It contains approximately 230 species that are mainly distributed in tropical and subtropical regions. Some species in this genus, such as E.monogynum and E.coca, have been used as folk medicines in India or South America for a long history. It is well known that Erythroxylum plants are rich in tropane alkaloids, and the representative member cocaine shows remarkable activity in human central nervous system. However, many other types of active compounds have also been found in Erythroxylum along with the broadening and deepening of phytochemical research. To date, a total of 383 compounds from Erythroxylum have been reported, among which only 186 tropane alkaloids have been reviewed in 2010. In this review, we summarized all remained 197 compounds characterized from 53 Erythroxylum species from 1960 to 2021, which include diterpenes, triterpenes, alkaloids, flavonoids, and other derivates, providing a comprehensive overview of phytoconstituents profile of Erythroxylum plants. In addition, the biological activities of representative phytochemicals and crude extracts were also highlighted. Graphical Abstract

show abstract

Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

Cited by 11 publications

References 13 publications

Untitled

Untitled

Degradação do contaminante emergente paracetamol empregando processos oxidativos avançados

Advances in chemistry and bioactivity of the genus Erythroxylum

Contact Info

Product

Resources

About