Cocalinho é uma comunidade quilombola localizada no norte do estado do Tocantins e, da mesma forma que outras comunidades de ancestralidade africana no Brasil, carece de assistência social adequada e de acesso aos serviços de saúde. Para entender o contexto atual dessa comunidade, vários parâmetros foram analisados: segurança alimentar, frequência de consumo alimentar, dados socioeconômicos e antropométricos, saúde bucal e prevalência de dentes cariados, ausentes e obturados. Os parâmetros avaliados indicaram, como esperado, uma grave falta de acesso à saúde em Cocalinho, o que reforça a necessidade de políticas públicas eficazes para atender às necessidades básicas dessa comunidade. Soluções voltadas ao incentivo da produção agroalimentar e à educação alimentar e nutricional que valorizem os alimentos regionais, além daquelas voltadas à garantia do acesso aos serviços de saúde, constituem estratégias potenciais para reduzir a pobreza e a má nutrição. Coletivamente, os dados destacam a importância de estudos interdisciplinares para melhor caracterizar as comunidades tradicionais, a fim de fornecer dados relevantes para políticas públicas adequadas.
The data indicated that FVL is significantly associated with VTE among young Brazilian patients, but also supported previous evidence that VTE is a multi-factorial disease, resulting from the interaction of genetic and acquired risk factors.
The A1 and B alleles of the ABO blood system have been associated with high levels of both factor VIII and von Willebrand factor and with a predisposition to venous thromboembolism (VTE). In this study, genotypes of the ABO system were determined by PCR-restriction fragment length polymorphism for 148 young VTE Brazilian patients and 233 unrelated control individuals. The blood group O was more frequent among the controls [odds ratio (OR), 0.21; 95% confidence interval (CI), 0.13-0.34; P = 0.000) and groups A and B (OR, 2.24; 95%, CI, 1.46-3.42; P = 0.000 and OR, 2.52; 95% CI, 1.42-4.48; P = 0.002, respectively) among patients. The patients' group was under Hardy-Weinberg equilibrium, whereas the control group was not (P < 0.0051), suggesting that natural selection might be acting in favor of carriers of the O blood group. When the allelic frequencies were compared through multivariate logistic regression analysis for adjustments of covariates, the alleles A1 (OR, 1.69; 95% CI, 1.17-2.45; P = 0.006), A2 (OR, 2.19; 95% CI, 1.24-3.87; P = 0.010), and B (OR, 2.65; 95% CI, 1.64-4.26; P = 0.000) were independently associated with VTE and may represent important risk factors to the development of VTE among young Brazilian patients. Thus, the inclusion of ABO blood group determination may be helpful to discriminate individuals with high risk for VTE allowing target intervention as well as to manage VTE in young patients.
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