The purpose of this study was to determine the effect of intervention by certified nurse specialist in psychiatric mental health nursing (PMHCNS) on depressive cancer patients. Method: The randomized controlled trial design was used. Inpatients from three hospitals were randomly allocated into the intervention (n = 34) or control group (n = 37). Participants in the former group received PMHCNS intervention while control participants were given a booklet about self-management of depressive symptoms. The primary outcome was scores of depression evaluated on the Patient Health Questionnaire (PHQ)-9 scale before and after intervention. Results: PHQ-9 scores improved in both groups. As a result of 2-way ANOVA, there were significant interaction effects between the intervention and time in the scores. Conclusion: The result of the study provided evidence to support that PMHCNS intervention improves depression.

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